Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   H1W98_RS04215 Genome accession   NZ_LR822026
Coordinates   807871..808545 (+) Length   224 a.a.
NCBI ID   WP_179974450.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_967     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 802871..813545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W98_RS04195 (STHERMO_0913) - 803998..804570 (-) 573 WP_179972994.1 ECF transporter S component -
  H1W98_RS04200 (STHERMO_0914) coaC 804598..805143 (-) 546 WP_180482046.1 phosphopantothenoylcysteine decarboxylase -
  H1W98_RS04205 (STHERMO_0915) - 805136..805819 (-) 684 WP_002948206.1 phosphopantothenate--cysteine ligase -
  H1W98_RS04210 (STHERMO_0916) - 806013..807683 (+) 1671 WP_113870374.1 formate--tetrahydrofolate ligase -
  H1W98_RS04215 (STHERMO_0917) ciaR 807871..808545 (+) 675 WP_179974450.1 response regulator transcription factor Regulator
  H1W98_RS10720 - 808535..809955 (+) 1421 Protein_789 sensor histidine kinase -
  H1W98_RS04235 (STHERMO_0921) rpsT 810043..810279 (-) 237 WP_179972893.1 30S ribosomal protein S20 -
  H1W98_RS04240 (STHERMO_0922) coaA 810348..811268 (-) 921 WP_179972894.1 type I pantothenate kinase -
  H1W98_RS04245 (STHERMO_0923) - 811576..812166 (+) 591 WP_180482044.1 class I SAM-dependent methyltransferase -
  H1W98_RS04255 - 812163..813406 (+) 1244 Protein_793 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25356.02 Da        Isoelectric Point: 4.2696

>NTDB_id=1131277 H1W98_RS04215 WP_179974450.1 807871..808545(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_967]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVIIMTA
KESLDDKGHGFKLGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTISFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1131277 H1W98_RS04215 WP_179974450.1 807871..808545(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_967]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCAGATGT
GATGCAAGTATTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTATTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTTAAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGAAAATTTGATCAAAATACTATTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACCTATGTGGGTGATAAAGAAGTAGAACTTCTCGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACTACTGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae D39

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae R6

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.996

99.554

0.866
  ciaR Streptococcus mutans UA159

85.268

100

0.853
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.778

100

0.379
  vicR Streptococcus mutans UA159

35.169

100

0.371
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362

Multiple sequence alignment