Detailed information NTG1131214

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H1X08_RS05970
• Genome accession: NZ_LR822025
• Coordinates: 1155799..1156473 (-)
• Length: 224 a.a.
• NCBI ID: WP_179974450.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_961
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1150799..1161473

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X08_RS05930	-	1150938..1152181 (-)	1244	Protein_1129	pyrimidine-nucleoside phosphorylase	-
H1X08_RS05940 (STHERMO_1365)	-	1152178..1152768 (-)	591	WP_180482044.1	class I SAM-dependent methyltransferase	-
H1X08_RS05945 (STHERMO_1366)	coaA	1153076..1153996 (+)	921	WP_179972894.1	type I pantothenate kinase	-
H1X08_RS05950 (STHERMO_1367)	rpsT	1154065..1154301 (+)	237	WP_179972893.1	30S ribosomal protein S20	-
H1X08_RS10770	-	1154389..1155809 (-)	1421	Protein_1133	sensor histidine kinase	-
H1X08_RS05970 (STHERMO_1371)	ciaR	1155799..1156473 (-)	675	WP_179974450.1	response regulator transcription factor	Regulator
H1X08_RS05975 (STHERMO_1372)	-	1156661..1158331 (-)	1671	WP_113870374.1	formate--tetrahydrofolate ligase	-
H1X08_RS05980 (STHERMO_1373)	-	1158525..1159208 (+)	684	WP_002948206.1	phosphopantothenate--cysteine ligase	-
H1X08_RS05985 (STHERMO_1374)	coaC	1159201..1159746 (+)	546	WP_180482046.1	phosphopantothenoylcysteine decarboxylase	-
H1X08_RS05990 (STHERMO_1375)	-	1159774..1160346 (+)	573	WP_179972994.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25356.02 Da
• Isoelectric Point: 4.2696

>NTDB_id=1131214 H1X08_RS05970 WP_179974450.1 1155799..1156473(-) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_961]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVIIMTA
KESLDDKGHGFKLGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTISFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1131214 H1X08_RS05970 WP_179974450.1 1155799..1156473(-) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_961]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCAGATGT
GATGCAAGTATTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTATTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTTAAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGAAAATTTGATCAAAATACTATTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACCTATGTGGGTGATAAAGAAGTAGAACTTCTCGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACTACTGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	85.268	100	0.853
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.778	100	0.379
vicR	Streptococcus mutans UA159	35.169	100	0.371
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362