Detailed information NTG1131210

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H1X08_RS05255
• Genome accession: NZ_LR822025
• Coordinates: 1030140..1030865 (-)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus isolate STH_CIRM_961
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1025140..1035865

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X08_RS05230 (STHERMO_1183)	pyrF	1025525..1026220 (-)	696	WP_011681116.1	orotidine-5'-phosphate decarboxylase	-
H1X08_RS05235 (STHERMO_1184)	csm6	1026421..1027512 (-)	1092	WP_101415612.1	type III-A CRISPR-associated CARF protein Csm6	-
H1X08_RS05240 (STHERMO_1185)	-	1027527..1028111 (-)	585	WP_232086162.1	hypothetical protein	-
H1X08_RS05250 (STHERMO_1187)	-	1028808..1030127 (-)	1320	WP_095559360.1	sensor histidine kinase	-
H1X08_RS05255 (STHERMO_1188)	comE/comE1	1030140..1030865 (-)	726	WP_179972946.1	LytR/AlgR family response regulator transcription factor	Regulator
H1X08_RS05260 (STHERMO_1189)	-	1031052..1031816 (-)	765	WP_232086914.1	DUF6261 family protein	-
H1X08_RS05265 (STHERMO_1190)	-	1032348..1033271 (-)	924	WP_179972945.1	LPXTG cell wall anchor domain-containing protein	-
H1X08_RS05270 (STHERMO_1191)	-	1033452..1033856 (-)	405	WP_015695682.1	hypothetical protein	-
H1X08_RS05275	-	1033914..1034006 (-)	93	Protein_998	Blp family class II bacteriocin	-
H1X08_RS05280 (STHERMO_1192)	-	1034220..1034531 (-)	312	WP_003066586.1	hypothetical protein	-
H1X08_RS05285 (STHERMO_1193)	-	1034620..1034850 (-)	231	WP_043878356.1	bacteriocin	-
H1X08_RS05290 (STHERMO_1195)	-	1035467..1035649 (-)	183	WP_180481989.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=1131210 H1X08_RS05255 WP_179972946.1 1030140..1030865(-) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_961]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=1131210 H1X08_RS05255 WP_179972946.1 1030140..1030865(-) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_961]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361