Detailed information NTG1131154

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H0513_RS05145
• Genome accession: NZ_LR822023
• Coordinates: 956663..957388 (+)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus isolate STH_CIRM_368
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 951663..962388

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0513_RS05110 (STHERMO_1133)	-	951880..952062 (+)	183	WP_006531883.1	Blp family class II bacteriocin	-
H0513_RS05115 (STHERMO_1134)	-	952679..952909 (+)	231	WP_043878356.1	bacteriocin	-
H0513_RS05120 (STHERMO_1135)	-	952998..953309 (+)	312	WP_003066586.1	hypothetical protein	-
H0513_RS05125	-	953523..953615 (+)	93	Protein_954	Blp family class II bacteriocin	-
H0513_RS05130 (STHERMO_1136)	-	953673..954077 (+)	405	WP_015695682.1	hypothetical protein	-
H0513_RS05135 (STHERMO_1137)	-	954258..955181 (+)	924	WP_179972945.1	LPXTG cell wall anchor domain-containing protein	-
H0513_RS05140 (STHERMO_1138)	-	955742..956476 (+)	735	WP_232086883.1	DUF6261 family protein	-
H0513_RS05145 (STHERMO_1139)	comE/comE1	956663..957388 (+)	726	WP_179972946.1	LytR/AlgR family response regulator transcription factor	Regulator
H0513_RS05150 (STHERMO_1140)	-	957401..958720 (+)	1320	WP_095559360.1	sensor histidine kinase	-
H0513_RS05155 (STHERMO_1141)	-	958741..958890 (-)	150	WP_006531893.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H0513_RS05165 (STHERMO_1142)	-	959417..960001 (+)	585	WP_232086162.1	hypothetical protein	-
H0513_RS05170 (STHERMO_1143)	csm6	960016..961107 (+)	1092	WP_101415612.1	type III-A CRISPR-associated CARF protein Csm6	-
H0513_RS05175 (STHERMO_1144)	pyrF	961308..962003 (+)	696	WP_011681116.1	orotidine-5'-phosphate decarboxylase	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=1131154 H0513_RS05145 WP_179972946.1 956663..957388(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_368]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=1131154 H0513_RS05145 WP_179972946.1 956663..957388(+) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_368]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361