Detailed information NTG1131092

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: H0514_RS05130
• Genome accession: NZ_LR822020
• Coordinates: 1008305..1009030 (-)
• Length: 241 a.a.
• NCBI ID: WP_179972946.1
• Uniprot ID: A0A7U7H0X6
• Organism: Streptococcus thermophilus isolate STH_CIRM_956
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1003305..1014030

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0514_RS05105 (STHERMO_1163)	pyrF	1003690..1004385 (-)	696	WP_011681116.1	orotidine-5'-phosphate decarboxylase	-
H0514_RS05110 (STHERMO_1164)	csm6	1004586..1005677 (-)	1092	WP_101415612.1	type III-A CRISPR-associated CARF protein Csm6	-
H0514_RS05115 (STHERMO_1165)	-	1005692..1006276 (-)	585	WP_232086162.1	hypothetical protein	-
H0514_RS05125 (STHERMO_1166)	-	1006973..1008292 (-)	1320	WP_095559360.1	sensor histidine kinase	-
H0514_RS05130 (STHERMO_1167)	comE/comE1	1008305..1009030 (-)	726	WP_179972946.1	LytR/AlgR family response regulator transcription factor	Regulator
H0514_RS05135 (STHERMO_1168)	-	1009217..1009981 (-)	765	WP_232086163.1	DUF6261 family protein	-
H0514_RS05140 (STHERMO_1169)	-	1010512..1011558 (-)	1047	WP_095559358.1	thioredoxin fold domain-containing protein	-
H0514_RS05145 (STHERMO_1170)	-	1011739..1012143 (-)	405	WP_015695682.1	hypothetical protein	-
H0514_RS05150	-	1012201..1012293 (-)	93	Protein_964	Blp family class II bacteriocin	-
H0514_RS05155 (STHERMO_1171)	-	1012507..1012818 (-)	312	WP_003066586.1	hypothetical protein	-
H0514_RS05160 (STHERMO_1172)	-	1012907..1013137 (-)	231	WP_043878356.1	bacteriocin	-
H0514_RS05165 (STHERMO_1173)	-	1013754..1013936 (-)	183	WP_006531883.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28020.99 Da
• Isoelectric Point: 5.2156

>NTDB_id=1131092 H0514_RS05130 WP_179972946.1 1008305..1009030(-) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_956]
MDIFVLEDDIPQQFRMERAINLVMESNNWHYRYLEISSNPDEIIAVAGNGEHQIFFLDLEIKGEEQQGIDVAKAIREKNS
TAIIVFVTTHSEFMLLTYQSLVGAIDFIDKGLNEEAFNERLFVCLKEAVKRQEGNFGEHSYLFHTPQAKVRVAYDDILFF
ETSPAPHRIILHTKNERTEFYATIAEVAKSDERLFRCHRSFVVNVDNIARFDMRYKLIYFEMGETCPVARAKVKLLQEKI
G

Nucleotide

• Length: 726 bp

>NTDB_id=1131092 H0514_RS05130 WP_179972946.1 1008305..1009030(-) (comE/comE1) [Streptococcus thermophilus isolate STH_CIRM_956]
GTGGATATTTTTGTACTCGAAGATGATATTCCCCAACAATTCCGAATGGAGCGTGCTATTAATCTTGTGATGGAATCAAA
TAACTGGCATTATCGGTATTTGGAGATTTCATCTAATCCTGATGAAATCATCGCAGTAGCAGGTAATGGTGAACATCAAA
TTTTCTTTCTTGATTTAGAAATTAAAGGTGAAGAGCAGCAAGGGATTGATGTTGCTAAAGCTATTCGTGAAAAAAATAGC
ACAGCTATTATTGTTTTTGTGACGACACATTCTGAATTCATGCTCTTAACCTATCAATCTTTAGTAGGTGCTATTGACTT
TATTGACAAAGGATTAAACGAAGAAGCGTTTAATGAACGCTTATTCGTTTGTCTTAAAGAAGCTGTCAAACGCCAAGAGG
GAAACTTTGGTGAACATTCCTACTTGTTTCATACCCCACAAGCCAAAGTGCGGGTAGCTTATGATGATATTTTATTTTTT
GAAACGTCACCAGCACCTCATCGTATTATTTTGCACACTAAGAACGAACGTACAGAATTTTATGCGACCATAGCAGAAGT
GGCAAAATCAGATGAACGTCTTTTTAGATGTCATCGTTCTTTTGTGGTTAACGTGGATAATATCGCTAGATTTGATATGA
GGTATAAGCTCATTTATTTTGAGATGGGAGAAACCTGTCCTGTAGCTAGGGCTAAGGTGAAATTATTACAGGAGAAAATT
GGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (150-240)

3D structure

• AlphaFold DB: A0A7U7H0X6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	65.823	98.34	0.647
comE/blpR	Streptococcus mutans UA159	46.091	100	0.465
comE/comE2	Streptococcus equinus JB1	44.167	99.585	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	35.06	100	0.365
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.06	100	0.365
agrA	Staphylococcus aureus N315	35.656	100	0.361