Detailed information NTG1130966

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H0511_RS04130
• Genome accession: NZ_LR822017
• Coordinates: 783747..784421 (+)
• Length: 224 a.a.
• NCBI ID: WP_179974450.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_336
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 778747..789421

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0511_RS04110 (STHERMO_0871)	-	779816..780388 (-)	573	WP_179974523.1	ECF transporter S component	-
H0511_RS04115 (STHERMO_0872)	coaC	780416..780961 (-)	546	WP_179974448.1	phosphopantothenoylcysteine decarboxylase	-
H0511_RS04120 (STHERMO_0873)	-	780954..781637 (-)	684	WP_179974449.1	phosphopantothenate--cysteine ligase	-
H0511_RS04125 (STHERMO_0874)	-	781888..783558 (+)	1671	WP_179972890.1	formate--tetrahydrofolate ligase	-
H0511_RS04130 (STHERMO_0875)	ciaR	783747..784421 (+)	675	WP_179974450.1	response regulator transcription factor	Regulator
H0511_RS04135 (STHERMO_0876)	ciaH	784411..785829 (+)	1419	WP_179974451.1	sensor histidine kinase	Regulator
H0511_RS04140 (STHERMO_0877)	rpsT	785917..786153 (-)	237	WP_179974452.1	30S ribosomal protein S20	-
H0511_RS04145 (STHERMO_0878)	coaA	786222..787142 (-)	921	WP_179974453.1	type I pantothenate kinase	-
H0511_RS04150 (STHERMO_0879)	-	787451..788044 (+)	594	WP_179974454.1	class I SAM-dependent methyltransferase	-
H0511_RS04160	-	788044..789269 (+)	1226	Protein_776	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25356.02 Da
• Isoelectric Point: 4.2696

>NTDB_id=1130966 H0511_RS04130 WP_179974450.1 783747..784421(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_336]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVIIMTA
KESLDDKGHGFKLGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTISFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=1130966 H0511_RS04130 WP_179974450.1 783747..784421(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_336]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCAGATGT
GATGCAAGTATTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTATTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTTAAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGAAAATTTGATCAAAATACTATTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACCTATGTGGGTGATAAAGAAGTAGAACTTCTCGGTAAAGAATTTGATTTATTGGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACTACTGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	85.268	100	0.853
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.778	100	0.379
vicR	Streptococcus mutans UA159	35.169	100	0.371
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362