Detailed information NTG1130834

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H0508_RS01415
• Genome accession: NZ_LR822014
• Coordinates: 264096..264995 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus isolate STH_CIRM_36
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 259096..269995

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0508_RS01395 (STHERMO_0282)	trkA	260222..261571 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
H0508_RS01400 (STHERMO_0283)	-	261829..262368 (+)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H0508_RS01405 (STHERMO_0284)	-	262680..263237 (+)	558	WP_002949523.1	ECF transporter S component	-
H0508_RS01410 (STHERMO_0285)	-	263240..263890 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
H0508_RS01415 (STHERMO_0286)	comR	264096..264995 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
H0508_RS09260 (STHERMO_0288)	-	265233..266411 (+)	1179	Protein_239	ABC transporter transmembrane domain-containing protein	-
H0508_RS01435 (STHERMO_0291)	-	266697..267265 (+)	569	Protein_240	ATP-binding cassette domain-containing protein	-
H0508_RS01440 (STHERMO_0292)	-	267373..267690 (+)	318	WP_011225454.1	DUF805 domain-containing protein	-
H0508_RS09380 (STHERMO_0295)	-	268177..268890 (-)	714	WP_232085846.1	DUF4153 domain-containing protein	-
H0508_RS01450 (STHERMO_0296)	-	269478..269993 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1130834 H0508_RS01415 WP_011225448.1 264096..264995(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_36]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1130834 H0508_RS01415 WP_011225448.1 264096..264995(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_36]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTAGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421