Detailed information NTG1130732

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: H0505_RS04260
• Genome accession: NZ_LR822012
• Coordinates: 810810..811649 (+)
• Length: 279 a.a.
• NCBI ID: WP_011227155.1
• Uniprot ID: A0A3G6JMX3
• Organism: Streptococcus thermophilus isolate STH_CIRM_30
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 805810..816649

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0505_RS04230 (STHERMO_0898)	-	806225..806752 (+)	528	WP_011681081.1	ECF transporter S component	-
H0505_RS04235 (STHERMO_0899)	-	806776..807291 (+)	516	WP_014608251.1	transcription repressor NadR	-
H0505_RS04240 (STHERMO_0900)	-	807386..808075 (+)	690	WP_046206437.1	XRE family transcriptional regulator	-
H0505_RS04245 (STHERMO_0901)	ylqF	808203..809057 (+)	855	WP_002950602.1	ribosome biogenesis GTPase YlqF	-
H0505_RS04250 (STHERMO_0902)	-	809044..809811 (+)	768	WP_002950603.1	ribonuclease HII	-
H0505_RS04255 (STHERMO_0903)	-	809822..810742 (+)	921	WP_179971317.1	ROK family protein	-
H0505_RS04260 (STHERMO_0904)	dprA	810810..811649 (+)	840	WP_011227155.1	DNA-processing protein DprA	Machinery gene
H0505_RS04265 (STHERMO_0905)	topA	811817..813961 (+)	2145	WP_179971318.1	type I DNA topoisomerase	-
H0505_RS04270 (STHERMO_0906)	-	814079..814903 (+)	825	WP_179971319.1	TraX family protein	-
H0505_RS04275 (STHERMO_0907)	-	814939..815598 (+)	660	WP_179971320.1	response regulator transcription factor	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31233.11 Da
• Isoelectric Point: 8.4489

>NTDB_id=1130732 H0505_RS04260 WP_011227155.1 810810..811649(+) (dprA) [Streptococcus thermophilus isolate STH_CIRM_30]
MNNFELFKLKAAGLTNLNILNILDYQKNQDKKLSLRDMAVVSKSKNAVLFMEKYKNLDVNQLKEDFQRFPTLSIFDKEYP
IELKHSYNPPVLLFYQGNIDLLSKPKLAVVGARKCSETGKQSVRKIVHELGNAFTIVSGLARGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHYPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDIISEFS

Nucleotide

• Length: 840 bp

>NTDB_id=1130732 H0505_RS04260 WP_011227155.1 810810..811649(+) (dprA) [Streptococcus thermophilus isolate STH_CIRM_30]
ATGAATAACTTTGAACTTTTTAAACTAAAAGCTGCTGGATTGACGAATTTAAACATCCTTAACATTTTAGACTATCAAAA
AAATCAAGATAAAAAATTGAGCTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTCTTTATGGAAAAAT
ACAAGAATTTAGATGTTAATCAGCTTAAGGAAGATTTTCAACGTTTTCCGACCTTATCAATTTTTGATAAGGAGTATCCC
ATTGAGCTGAAACATTCCTATAATCCTCCTGTCCTCCTCTTTTATCAAGGGAATATTGATTTGCTAAGTAAACCCAAGTT
AGCAGTAGTTGGTGCCAGAAAGTGTTCTGAAACAGGCAAACAGTCTGTTCGAAAAATTGTTCATGAACTTGGGAATGCCT
TTACTATTGTAAGTGGCTTGGCGCGTGGAATTGATACTTGTGCTCATATGGAGGCCTTAAAAAATAAAGGTAACACCATT
GCAGTTATCGGGACTGGGCTAGACGTATATTATCCTAAAGAAAACAAAGCTTTACAGGACTATATGGCTAAAAATCATTT
AGTTCTTACAGAATATGGACCGGGTGAACAGCCACTTAAATACCATTATCCTGAACGAAATCGGATAATTTCTGGATTGT
GTCAAGGGGTTATGGTGGTTGAAGCCAAGCTTCGCTCGGGAAGTCTTATTACTTGTGAGCGTGCAATGGAAGAAGGAAGA
GATGTTTTCGCTATACCAGGAAATATTTTAGATGGAAAATCGGATGGATGCCATCACCTCATTCAAGAGGGCGCAAAGTG
CATTACTACAGGATTTGACATCATTTCAGAATTTTCATAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A3G6JMX3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	71.685	100	0.717
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA/cilB/dalA	Streptococcus mitis SK321	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	60.072	99.642	0.599
dprA	Latilactobacillus sakei subsp. sakei 23K	39.768	92.832	0.369
dprA	Bacillus subtilis subsp. subtilis str. 168	48.095	75.269	0.362