Detailed information NTG1130716

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H0505_RS01450
• Genome accession: NZ_LR822012
• Coordinates: 265464..266363 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus isolate STH_CIRM_30
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 260464..271363

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0505_RS01430 (STHERMO_0282)	trkA	261600..262949 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
H0505_RS01435 (STHERMO_0283)	-	263238..263747 (+)	510	WP_179971169.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H0505_RS01440 (STHERMO_0284)	-	264059..264616 (+)	558	WP_002949523.1	ECF transporter S component	-
H0505_RS01445 (STHERMO_0285)	-	264619..265269 (+)	651	WP_179971170.1	phosphatase PAP2 family protein	-
H0505_RS01450 (STHERMO_0286)	comR	265464..266363 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
H0505_RS10195	-	266601..267779 (+)	1179	Protein_237	ABC transporter transmembrane domain-containing protein	-
H0505_RS10200 (STHERMO_0290)	comA	267801..268634 (+)	834	WP_269149495.1	ATP-binding cassette domain-containing protein	Regulator
H0505_RS01460 (STHERMO_0291)	-	268742..269059 (+)	318	WP_179970762.1	DUF805 domain-containing protein	-
H0505_RS09475	-	269275..269622 (-)	348	WP_232085744.1	DUF4153 domain-containing protein	-
H0505_RS09480 (STHERMO_0294)	-	269547..270167 (-)	621	WP_232085704.1	DUF4153 domain-containing protein	-
H0505_RS01470 (STHERMO_0295)	-	270848..271363 (+)	516	WP_002949547.1	AmiS/UreI family transporter	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1130716 H0505_RS01450 WP_011225448.1 265464..266363(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_30]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1130716 H0505_RS01450 WP_011225448.1 265464..266363(+) (comR) [Streptococcus thermophilus isolate STH_CIRM_30]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421