Detailed information NTG1130684

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H0504_RS07585
• Genome accession: NZ_LR822011
• Coordinates: 1476616..1477515 (-)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 1471616..1482515

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS07545 (STHERMO_1688)	-	1471618..1472133 (-)	516	WP_002949547.1	AmiS/UreI family transporter	-
H0504_RS09785 (STHERMO_1689)	-	1472634..1473434 (+)	801	WP_011225455.1	hypothetical protein	-
H0504_RS07555 (STHERMO_1692)	-	1473921..1474238 (-)	318	WP_011225454.1	DUF805 domain-containing protein	-
H0504_RS07560 (STHERMO_1693)	-	1474346..1474914 (-)	569	Protein_1458	ATP-binding cassette domain-containing protein	-
H0504_RS07575 (STHERMO_1696)	-	1475200..1476441 (-)	1242	Protein_1459	ABC transporter transmembrane domain-containing protein	-
H0504_RS07585 (STHERMO_1698)	comR	1476616..1477515 (-)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
H0504_RS07590 (STHERMO_1699)	-	1477721..1478371 (-)	651	WP_011225447.1	phosphatase PAP2 family protein	-
H0504_RS07595 (STHERMO_1700)	-	1478374..1478931 (-)	558	WP_002949523.1	ECF transporter S component	-
H0504_RS07600 (STHERMO_1701)	-	1479243..1479782 (-)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
H0504_RS07605 (STHERMO_1702)	trkA	1480040..1481389 (+)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=1130684 H0504_RS07585 WP_011225448.1 1476616..1477515(-) (comR) [Streptococcus thermophilus isolate STH_CIRM_23]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=1130684 H0504_RS07585 WP_011225448.1 1476616..1477515(-) (comR) [Streptococcus thermophilus isolate STH_CIRM_23]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTAGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421