Detailed information NTG1130669

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: H0504_RS04750
• Genome accession: NZ_LR822011
• Coordinates: 918948..919787 (-)
• Length: 279 a.a.
• NCBI ID: WP_011225887.1
• Uniprot ID: Q5M4N4
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 913948..924787

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS04735 (STHERMO_1053)	-	915000..915659 (-)	660	WP_011225890.1	response regulator transcription factor	-
H0504_RS04740 (STHERMO_1054)	-	915695..916519 (-)	825	WP_011225889.1	TraX family protein	-
H0504_RS04745 (STHERMO_1055)	topA	916636..918780 (-)	2145	WP_179971719.1	type I DNA topoisomerase	-
H0504_RS04750 (STHERMO_1057)	dprA	918948..919787 (-)	840	WP_011225887.1	DNA-processing protein DprA	Machinery gene
H0504_RS04755 (STHERMO_1058)	-	919855..920775 (-)	921	WP_002950604.1	ROK family protein	-
H0504_RS04760 (STHERMO_1059)	-	920786..921553 (-)	768	WP_041827018.1	ribonuclease HII	-
H0504_RS04765 (STHERMO_1060)	ylqF	921540..922394 (-)	855	WP_002950602.1	ribosome biogenesis GTPase YlqF	-
H0504_RS04770 (STHERMO_1061)	-	922522..923211 (-)	690	WP_011225885.1	XRE family transcriptional regulator	-
H0504_RS04775 (STHERMO_1062)	-	923306..923821 (-)	516	WP_011225884.1	transcription repressor NadR	-
H0504_RS04780 (STHERMO_1063)	-	923845..924372 (-)	528	WP_041827017.1	ECF transporter S component	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31247.18 Da
• Isoelectric Point: 8.6571

>NTDB_id=1130669 H0504_RS04750 WP_011225887.1 918948..919787(-) (dprA) [Streptococcus thermophilus isolate STH_CIRM_23]
MNNFELFKLKAAGLTNLNILNILDYQKNQDKKLSLRDMAVVSKSKNAVLFMEKYKNLDVKQLKEDFQRFPTLSIFDKEYP
IELKHSYNPPVLLFYQGNIDLLSKPKLAVVGARKCSETGKQSVRKIVHELGNAFTIVSGLARGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHYPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDIISEFS

Nucleotide

• Length: 840 bp

>NTDB_id=1130669 H0504_RS04750 WP_011225887.1 918948..919787(-) (dprA) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGAATAACTTTGAACTTTTTAAACTAAAAGCTGCTGGATTGACGAATTTAAACATCCTTAACATTTTAGACTATCAAAA
AAATCAAGATAAAAAATTGAGCTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTCTTTATGGAAAAAT
ACAAGAATTTAGATGTTAAGCAGCTTAAGGAAGATTTTCAACGTTTTCCGACCTTATCAATTTTTGATAAGGAGTATCCC
ATTGAGCTGAAACATTCCTATAATCCTCCTGTCCTCCTCTTTTATCAAGGGAATATTGATTTGCTAAGTAAACCCAAGTT
AGCAGTAGTTGGTGCCAGAAAGTGTTCTGAAACAGGCAAACAGTCTGTTCGAAAAATTGTTCATGAACTTGGGAATGCTT
TTACTATTGTAAGTGGCTTGGCGCGTGGAATTGATACTTGTGCTCATATGGAGGCCTTAAAAAATAAAGGTAACACCATT
GCAGTTATCGGGACTGGGCTAGACGTATATTATCCTAAAGAAAACAAAGCTTTACAGGACTATATGGCTAAAAATCATTT
AGTTCTTACAGAATACGGACCGGGTGAACAGCCACTTAAATACCATTATCCTGAACGAAATCGGATAATTTCTGGATTGT
GTCAAGGGGTTATGGTGGTTGAAGCCAAGCTTCGCTCGGGAAGTCTTATTACTTGTGAGCGTGCAATGGAAGAAGGAAGA
GATGTTTTCGCCATACCAGGAAATATTTTAGATGGAAAATCGGATGGATGCCATCACCTCATTCAAGAGGGCGCAAAGTG
CATTACTACAGGATTTGACATCATTTCAGAATTTTCATAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: Q5M4N4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	72.043	100	0.72
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA/cilB/dalA	Streptococcus mitis SK321	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	60.432	99.642	0.602
dprA	Latilactobacillus sakei subsp. sakei 23K	39.768	92.832	0.369
dprA	Bacillus subtilis subsp. subtilis str. 168	48.095	75.269	0.362