Detailed information NTG1130666

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: H0504_RS03700
• Genome accession: NZ_LR822011
• Coordinates: 724087..724794 (+)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 719087..729794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS03670 (STHERMO_0796)	-	719368..719556 (+)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-
H0504_RS03675 (STHERMO_0797)	endA	719618..720499 (+)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
H0504_RS03680 (STHERMO_0798)	-	720570..721220 (-)	651	WP_011226088.1	amino acid ABC transporter permease	-
H0504_RS03685 (STHERMO_0799)	-	721232..721930 (-)	699	WP_011226087.1	amino acid ABC transporter permease	-
H0504_RS03690 (STHERMO_0800)	-	721948..722781 (-)	834	WP_011226086.1	transporter substrate-binding domain-containing protein	-
H0504_RS03695 (STHERMO_0801)	-	722793..723560 (-)	768	WP_011226085.1	amino acid ABC transporter ATP-binding protein	-
H0504_RS03700 (STHERMO_0803)	vicR	724087..724794 (+)	708	WP_011226084.1	response regulator YycF	Regulator
H0504_RS03705 (STHERMO_0804)	vicK	724787..726127 (+)	1341	WP_011226083.1	cell wall metabolism sensor histidine kinase VicK	Regulator
H0504_RS03710 (STHERMO_0805)	vicX	726133..726945 (+)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
H0504_RS03715	-	727005..727366 (+)	362	Protein_701	YbaN family protein	-
H0504_RS03720 (STHERMO_0806)	-	727418..728632 (-)	1215	WP_004197368.1	aminoacyltransferase	-
H0504_RS03725 (STHERMO_0807)	yidA	728634..729443 (-)	810	WP_011226081.1	sugar-phosphatase	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=1130666 H0504_RS03700 WP_011226084.1 724087..724794(+) (vicR) [Streptococcus thermophilus isolate STH_CIRM_23]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=1130666 H0504_RS03700 WP_011226084.1 724087..724794(+) (vicR) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387