Detailed information NTG1130665

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: H0504_RS03675
• Genome accession: NZ_LR822011
• Coordinates: 719618..720499 (+)
• Length: 293 a.a.
• NCBI ID: WP_011226089.1
• Uniprot ID: Q5M441
• Organism: Streptococcus thermophilus isolate STH_CIRM_23
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 714618..725499

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0504_RS09540 (STHERMO_0791)	-	716118..716354 (+)	237	WP_011226093.1	DUF4832 domain-containing protein	-
H0504_RS09545 (STHERMO_0792)	-	716370..716573 (+)	204	WP_011226092.1	hypothetical protein	-
H0504_RS03655 (STHERMO_0793)	galE	716588..717601 (+)	1014	WP_002946961.1	UDP-glucose 4-epimerase GalE	-
H0504_RS03660 (STHERMO_0794)	-	717789..718025 (+)	237	WP_002946959.1	DUF1146 family protein	-
H0504_RS03665 (STHERMO_0795)	murA	718095..719366 (+)	1272	WP_041828250.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
H0504_RS03670 (STHERMO_0796)	-	719368..719556 (+)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-
H0504_RS03675 (STHERMO_0797)	endA	719618..720499 (+)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
H0504_RS03680 (STHERMO_0798)	-	720570..721220 (-)	651	WP_011226088.1	amino acid ABC transporter permease	-
H0504_RS03685 (STHERMO_0799)	-	721232..721930 (-)	699	WP_011226087.1	amino acid ABC transporter permease	-
H0504_RS03690 (STHERMO_0800)	-	721948..722781 (-)	834	WP_011226086.1	transporter substrate-binding domain-containing protein	-
H0504_RS03695 (STHERMO_0801)	-	722793..723560 (-)	768	WP_011226085.1	amino acid ABC transporter ATP-binding protein	-
H0504_RS03700 (STHERMO_0803)	vicR	724087..724794 (+)	708	WP_011226084.1	response regulator YycF	Regulator

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 31757.50 Da
• Isoelectric Point: 10.1789

>NTDB_id=1130665 H0504_RS03675 WP_011226089.1 719618..720499(+) (endA) [Streptococcus thermophilus isolate STH_CIRM_23]
MAKRKTSLTNKQKRQLVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVAGKSNKSIKSNGSTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINRNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDSSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide

• Length: 882 bp

>NTDB_id=1130665 H0504_RS03675 WP_011226089.1 719618..720499(+) (endA) [Streptococcus thermophilus isolate STH_CIRM_23]
ATGGCAAAAAGAAAGACATCTTTGACAAATAAACAGAAACGTCAGTTAGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGTAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTGCAGGGAAAT
CTAACAAATCCATTAAATCTAATGGTTCAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGGGCCTACATTATTAATAGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCCTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAGTTCTACAGGCCAAAACTATTATGAAAGCCTAGTACGAAAAGCCCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCCTGATTTATGAAGGAGAGAATCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGCTC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATTACACTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (101-266)

3D structure

• AlphaFold DB: Q5M441

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	72.803	81.57	0.594
endA	Streptococcus pneumoniae D39	72.803	81.57	0.594
endA	Streptococcus pneumoniae R6	72.803	81.57	0.594
endA	Streptococcus pneumoniae TIGR4	72.803	81.57	0.594