Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   H0501_RS04075 Genome accession   NZ_LR822008
Coordinates   785830..786504 (+) Length   224 a.a.
NCBI ID   WP_084829541.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_18     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 780830..791504
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0501_RS04055 (STHERMO_0857) - 781959..782531 (-) 573 WP_011681047.1 ECF transporter S component -
  H0501_RS04060 (STHERMO_0858) coaC 782559..783104 (-) 546 WP_022096596.1 phosphopantothenoylcysteine decarboxylase -
  H0501_RS04065 (STHERMO_0859) - 783097..783780 (-) 684 WP_002948206.1 phosphopantothenate--cysteine ligase -
  H0501_RS04070 (STHERMO_0860) - 783974..785644 (+) 1671 WP_002950463.1 formate--tetrahydrofolate ligase -
  H0501_RS04075 (STHERMO_0861) ciaR 785830..786504 (+) 675 WP_084829541.1 response regulator transcription factor Regulator
  H0501_RS09930 - 786494..787912 (+) 1419 Protein_760 sensor histidine kinase -
  H0501_RS04095 - 788012..789582 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  H0501_RS04100 (STHERMO_0867) rpsT 789687..789923 (-) 237 WP_002947597.1 30S ribosomal protein S20 -
  H0501_RS04105 (STHERMO_0868) coaA 789992..790912 (-) 921 WP_002950487.1 type I pantothenate kinase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25385.95 Da        Isoelectric Point: 4.1928

>NTDB_id=1130496 H0501_RS04075 WP_084829541.1 785830..786504(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_18]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVLIITA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTFSFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTNVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1130496 H0501_RS04075 WP_084829541.1 785830..786504(+) (ciaR) [Streptococcus thermophilus isolate STH_CIRM_18]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTCTTATCATAACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGTAAATTTGATCAAAATACTTTTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACTTATGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTAGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCACAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACCAATGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae D39

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae R6

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.996

99.554

0.866
  ciaR Streptococcus mutans UA159

85.268

100

0.853
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

100

0.371
  vicR Streptococcus mutans UA159

35.169

100

0.371
  micA Streptococcus pneumoniae Cp1015

34.746

100

0.366

Multiple sequence alignment