Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GPW68_RS04810 Genome accession   NZ_LR738723
Coordinates   946905..947576 (+) Length   223 a.a.
NCBI ID   WP_009909965.1    Uniprot ID   A0A075SH40
Organism   Streptococcus suis isolate GD-0088     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 941905..952576
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GPW68_RS04780 pstC 942088..943005 (+) 918 WP_002937619.1 phosphate ABC transporter permease subunit PstC -
  GPW68_RS04785 pstA 942995..943882 (+) 888 WP_002937616.1 phosphate ABC transporter permease PstA -
  GPW68_RS04790 pstB 943907..944710 (+) 804 WP_002940866.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW68_RS04795 pstB 944722..945480 (+) 759 WP_074389058.1 phosphate ABC transporter ATP-binding protein PstB -
  GPW68_RS04800 phoU 945509..946165 (+) 657 WP_002937611.1 phosphate signaling complex protein PhoU -
  GPW68_RS04805 - 946331..946711 (+) 381 WP_023369940.1 hypothetical protein -
  GPW68_RS04810 ciaR 946905..947576 (+) 672 WP_009909965.1 response regulator transcription factor Regulator
  GPW68_RS04815 ciaH 947569..948948 (+) 1380 WP_074389057.1 sensor histidine kinase Regulator
  GPW68_RS04820 - 949272..950501 (+) 1230 WP_023369936.1 transglutaminase domain-containing protein -
  GPW68_RS04825 tnpA 950867..951340 (-) 474 WP_024378560.1 IS200/IS605 family transposase -
  GPW68_RS04830 rpsT 951514..951762 (-) 249 WP_012027069.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 25290.00 Da        Isoelectric Point: 4.2183

>NTDB_id=1129553 GPW68_RS04810 WP_009909965.1 946905..947576(+) (ciaR) [Streptococcus suis isolate GD-0088]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide


Download         Length: 672 bp        

>NTDB_id=1129553 GPW68_RS04810 WP_009909965.1 946905..947576(+) (ciaR) [Streptococcus suis isolate GD-0088]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SH40

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

90.135

100

0.901
  ciaR Streptococcus pneumoniae Rx1

88.341

100

0.883
  ciaR Streptococcus pneumoniae D39

88.341

100

0.883
  ciaR Streptococcus pneumoniae R6

88.341

100

0.883
  ciaR Streptococcus pneumoniae TIGR4

88.341

100

0.883
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.496

100

0.39
  vicR Streptococcus mutans UA159

35.47

100

0.372
  covR Streptococcus salivarius strain HSISS4

35.841

100

0.363

Multiple sequence alignment