Detailed information NTG1127925

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FGL22_RS05695
• Genome accession: NZ_LR594048
• Coordinates: 1119515..1120189 (-)
• Length: 224 a.a.
• NCBI ID: WP_003060678.1
• Uniprot ID: A0AAE9R380
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1114515..1125189

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL22_RS05670 (NCTC11556_01169)	-	1114700..1115977 (-)	1278	WP_015017041.1	pyrimidine-nucleoside phosphorylase	-
FGL22_RS05675 (NCTC11556_01170)	-	1115964..1116563 (-)	600	WP_037589902.1	class I SAM-dependent methyltransferase	-
FGL22_RS05680 (NCTC11556_01171)	coaA	1116832..1117752 (+)	921	WP_003058858.1	type I pantothenate kinase	-
FGL22_RS05685 (NCTC11556_01172)	rpsT	1117806..1118054 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
FGL22_RS05690 (NCTC11556_01173)	ciaH	1118212..1119522 (-)	1311	WP_012766987.1	HAMP domain-containing sensor histidine kinase	Regulator
FGL22_RS05695 (NCTC11556_01174)	ciaR	1119515..1120189 (-)	675	WP_003060678.1	response regulator transcription factor	Regulator
FGL22_RS05700 (NCTC11556_01175)	-	1120393..1122930 (-)	2538	WP_003061495.1	M1 family metallopeptidase	-
FGL22_RS05705 (NCTC11556_01176)	phoU	1123131..1123784 (-)	654	WP_003057760.1	phosphate signaling complex protein PhoU	-
FGL22_RS05710 (NCTC11556_01177)	pstB	1123862..1124620 (-)	759	WP_065355298.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25601.58 Da
• Isoelectric Point: 4.4684

>NTDB_id=1127925 FGL22_RS05695 WP_003060678.1 1119515..1120189(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide

• Length: 675 bp

>NTDB_id=1127925 FGL22_RS05695 WP_003060678.1 1119515..1120189(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGCTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (5-112)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae D39	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae R6	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae TIGR4	84.615	98.661	0.835
ciaR	Streptococcus mutans UA159	84.163	98.661	0.83
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.326	100	0.388
vicR	Streptococcus mutans UA159	35.443	100	0.375