Detailed information NTG1127826

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FGL18_RS10645
• Genome accession: NZ_LR594046
• Coordinates: 2198156..2199376 (+)
• Length: 406 a.a.
• NCBI ID: WP_138126917.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae strain NCTC6403
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2195946..2197466	2198156..2199376	flank	690

Gene organization within MGE regions

Location: 2195946..2199376

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL18_RS10635 (NCTC6403_02182)	-	2195946..2197466 (+)	1521	WP_138126913.1	IS1182 family transposase	-
FGL18_RS10640 (NCTC6403_02183)	rlmH	2197467..2197946 (-)	480	WP_138126915.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGL18_RS10645 (NCTC6403_02184)	htrA	2198156..2199376 (+)	1221	WP_138126917.1	trypsin-like peptidase domain-containing protein	Regulator

Sequence

Protein

• Length: 406 a.a.
• Molecular weight: 42856.29 Da
• Isoelectric Point: 5.2394

>NTDB_id=1127826 FGL18_RS10645 WP_138126917.1 2198156..2199376(+) (htrA) [Streptococcus dysgalactiae strain NCTC6403]
MPSMKHILKSLGILLIGFLGGLLAIFTFNATQQSSSTSHTGSATTSEMVFNNTTDTTKAVKVVQNAVVSVINYQADPSSS
ISNPYTKLFGEDQTRENKDTELSIFREGSGVIYRKNGDSAYVITNNHVIDGAKRIEILMADGTKVIGELVGADTYSDLAV
VKVASDKIETVAKFADSTKLNVGEVAIAIGSPLGTQYANSVTEGIVSSLSRTVTLKNEDGDTVSTNAIQTDAAINPGNSG
GPLINIEGQVIGINSSKISSTPAGDNGNRGSIEGIGFAIPSSDVVKIIKQLEKYGEVIRPALGIHMVNLNDLSTNALYEI
NIPTGVTGGIVVASVQDGMPASGKLAQYDVITEIDGKAVNSISDLQSNLYGHDINDTIKVTFYRGTTKKKADITLTKTTQ
DLTKKQ

Nucleotide

• Length: 1221 bp

>NTDB_id=1127826 FGL18_RS10645 WP_138126917.1 2198156..2199376(+) (htrA) [Streptococcus dysgalactiae strain NCTC6403]
ATGCCATCTATGAAACATATCTTAAAATCCTTAGGCATTTTACTCATTGGATTTTTAGGAGGATTGTTAGCAATTTTCAC
CTTTAATGCTACTCAACAGTCTTCCTCTACCTCACATACTGGTAGTGCGACGACGAGTGAGATGGTTTTTAATAATACTA
CTGACACAACGAAAGCGGTTAAAGTCGTTCAAAATGCAGTAGTATCAGTGATTAACTATCAAGCAGATCCTTCTTCATCT
ATTTCAAATCCCTACACAAAACTCTTTGGAGAAGATCAAACAAGAGAAAATAAAGATACCGAGTTATCTATTTTTAGAGA
GGGTTCTGGTGTTATTTATCGAAAAAATGGTGATTCTGCGTACGTTATTACTAATAATCATGTCATTGACGGTGCAAAGC
GAATTGAAATTCTTATGGCAGATGGAACCAAAGTCATAGGAGAGTTAGTTGGAGCTGATACATATTCTGACTTGGCGGTT
GTTAAAGTTGCCTCAGATAAAATTGAGACAGTTGCTAAATTTGCAGATTCTACTAAGCTGAATGTTGGAGAAGTTGCTAT
CGCAATCGGTAGCCCACTAGGAACTCAGTACGCCAATTCCGTTACAGAAGGAATTGTTTCTAGTCTCAGTCGTACCGTTA
CCTTAAAAAATGAAGATGGGGACACTGTTTCAACAAATGCCATTCAAACTGATGCTGCTATTAATCCTGGAAACTCTGGT
GGTCCCCTTATTAATATTGAAGGACAGGTTATTGGTATCAATTCAAGTAAAATTTCTTCTACACCTGCTGGAGATAACGG
TAATAGAGGATCTATTGAAGGTATTGGATTTGCAATCCCATCTAGTGATGTTGTTAAAATAATCAAGCAATTAGAGAAGT
ATGGTGAAGTCATTAGACCAGCCCTTGGAATTCATATGGTCAACTTAAATGACTTATCTACTAATGCTCTCTATGAAATC
AATATCCCTACGGGTGTAACTGGTGGGATTGTGGTCGCTTCTGTTCAAGATGGAATGCCAGCTAGTGGTAAACTTGCCCA
GTACGACGTTATTACTGAAATTGATGGTAAAGCCGTCAACTCAATTAGTGATCTTCAAAGCAACCTATACGGCCATGACA
TTAACGATACCATCAAGGTAACCTTTTATAGAGGGACAACCAAGAAAAAAGCAGATATTACCTTAACTAAAACAACCCAG
GATTTGACCAAAAAGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• PDZ domain (PDZ_2) (300-395)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	58.458	99.015	0.579
htrA	Streptococcus mitis NCTC 12261	53.563	100	0.537
htrA	Streptococcus pneumoniae Rx1	53.563	100	0.537
htrA	Streptococcus pneumoniae D39	53.563	100	0.537
htrA	Streptococcus pneumoniae R6	53.563	100	0.537
htrA	Streptococcus pneumoniae TIGR4	53.563	100	0.537
htrA	Streptococcus gordonii str. Challis substr. CH1	53.465	99.507	0.532