Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FGL18_RS05675 Genome accession   NZ_LR594046
Coordinates   1168788..1169462 (-) Length   224 a.a.
NCBI ID   WP_138125684.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae strain NCTC6403     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1163788..1174462
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL18_RS05650 (NCTC6403_01163) - 1163973..1165250 (-) 1278 WP_138125676.1 pyrimidine-nucleoside phosphorylase -
  FGL18_RS05655 (NCTC6403_01164) - 1165237..1165836 (-) 600 WP_138125678.1 class I SAM-dependent methyltransferase -
  FGL18_RS05660 (NCTC6403_01165) coaA 1166105..1167025 (+) 921 WP_138125680.1 type I pantothenate kinase -
  FGL18_RS05665 (NCTC6403_01166) rpsT 1167079..1167327 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  FGL18_RS05670 (NCTC6403_01167) ciaH 1167485..1168795 (-) 1311 WP_138125682.1 HAMP domain-containing sensor histidine kinase Regulator
  FGL18_RS05675 (NCTC6403_01168) ciaR 1168788..1169462 (-) 675 WP_138125684.1 response regulator transcription factor Regulator
  FGL18_RS05680 (NCTC6403_01169) - 1169666..1172203 (-) 2538 WP_138125686.1 M1 family metallopeptidase -
  FGL18_RS05685 (NCTC6403_01170) phoU 1172404..1173057 (-) 654 WP_003057760.1 phosphate signaling complex protein PhoU -
  FGL18_RS05690 (NCTC6403_01171) pstB 1173135..1173893 (-) 759 WP_003057749.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25601.57 Da        Isoelectric Point: 4.4123

>NTDB_id=1127806 FGL18_RS05675 WP_138125684.1 1168788..1169462(-) (ciaR) [Streptococcus dysgalactiae strain NCTC6403]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLVFGNVVVDLGQKEVQVDGQPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1127806 FGL18_RS05675 WP_138125684.1 1168788..1169462(-) (ciaR) [Streptococcus dysgalactiae strain NCTC6403]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGTCTTTGGGAACGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCAGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTGTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  ciaR Streptococcus mutans UA159

84.163

98.661

0.83
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

34.322

100

0.362

Multiple sequence alignment