Detailed information NTG1127747

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FGL14_RS05990
• Genome accession: NZ_LR594045
• Coordinates: 1144504..1145178 (-)
• Length: 224 a.a.
• NCBI ID: WP_003060678.1
• Uniprot ID: A0AAE9R380
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1139504..1150178

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL14_RS05965 (NCTC9413_01231)	-	1139690..1140967 (-)	1278	WP_015017041.1	pyrimidine-nucleoside phosphorylase	-
FGL14_RS05970 (NCTC9413_01232)	-	1140954..1141553 (-)	600	WP_015057597.1	class I SAM-dependent methyltransferase	-
FGL14_RS05975 (NCTC9413_01233)	coaA	1141821..1142741 (+)	921	WP_048327791.1	type I pantothenate kinase	-
FGL14_RS05980 (NCTC9413_01234)	rpsT	1142795..1143043 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
FGL14_RS05985 (NCTC9413_01235)	ciaH	1143201..1144511 (-)	1311	WP_138083874.1	HAMP domain-containing sensor histidine kinase	Regulator
FGL14_RS05990 (NCTC9413_01236)	ciaR	1144504..1145178 (-)	675	WP_003060678.1	response regulator transcription factor	Regulator
FGL14_RS05995 (NCTC9413_01237)	-	1145382..1147919 (-)	2538	WP_138083875.1	M1 family metallopeptidase	-
FGL14_RS06000 (NCTC9413_01238)	phoU	1148120..1148773 (-)	654	WP_003057760.1	phosphate signaling complex protein PhoU	-
FGL14_RS06005 (NCTC9413_01239)	pstB	1148851..1149609 (-)	759	WP_003057749.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25601.58 Da
• Isoelectric Point: 4.4684

>NTDB_id=1127747 FGL14_RS05990 WP_003060678.1 1144504..1145178(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide

• Length: 675 bp

>NTDB_id=1127747 FGL14_RS05990 WP_003060678.1 1144504..1145178(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGCTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACAGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (5-112)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae D39	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae R6	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae TIGR4	84.615	98.661	0.835
ciaR	Streptococcus mutans UA159	84.163	98.661	0.83
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.326	100	0.388
vicR	Streptococcus mutans UA159	35.443	100	0.375