Detailed information NTG1127713

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FGL14_RS00320
• Genome accession: NZ_LR594045
• Coordinates: 36523..37434 (+)
• Length: 303 a.a.
• NCBI ID: WP_003060893.1
• Uniprot ID: A0AAE9U6L1
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 31523..42434

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL14_RS00300 (NCTC9413_00059)	purE	33028..33516 (+)	489	WP_015016518.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FGL14_RS00305 (NCTC9413_00060)	purK	33503..34585 (+)	1083	WP_138083646.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FGL14_RS00310 (NCTC9413_00061)	-	34714..34941 (+)	228	WP_022554087.1	hypothetical protein	-
FGL14_RS00315 (NCTC9413_00062)	purB	35089..36381 (+)	1293	WP_022554088.1	adenylosuccinate lyase	-
FGL14_RS00320 (NCTC9413_00063)	comR	36523..37434 (+)	912	WP_003060893.1	XRE family transcriptional regulator	Regulator
FGL14_RS11380 (NCTC9413_00064)	comS	37521..37619 (+)	99	WP_014611913.1	quorum-sensing system DWW-type pheromone	Regulator
FGL14_RS00325 (NCTC9413_00065)	ruvB	37653..38651 (+)	999	WP_138083647.1	Holliday junction branch migration DNA helicase RuvB	-
FGL14_RS00330 (NCTC9413_00066)	-	38786..39217 (+)	432	WP_003059365.1	low molecular weight protein-tyrosine-phosphatase	-
FGL14_RS00335 (NCTC9413_00067)	-	39246..39647 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
FGL14_RS00340 (NCTC9413_00068)	-	39644..41419 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35995.62 Da
• Isoelectric Point: 4.7392

>NTDB_id=1127713 FGL14_RS00320 WP_003060893.1 36523..37434(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=1127713 FGL14_RS00320 WP_003060893.1 36523..37434(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.389	99.34	0.828
comR	Streptococcus pyogenes MGAS8232	55.629	99.67	0.554
comR	Streptococcus mutans UA159	46.154	98.68	0.455
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363