Detailed information NTG1127168

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: FGK99_RS02485
• Genome accession: NZ_LR594033
• Coordinates: 517457..519598 (+)
• Length: 713 a.a.
• NCBI ID: WP_138118889.1
• Uniprot ID: -
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC4675
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	515491..525828	517457..519598	within	0

Gene organization within MGE regions

Location: 515491..525828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK99_RS02475 (NCTC4675_00504)	-	516469..516609 (+)	141	WP_138118885.1	competence protein	-
FGK99_RS10050 (NCTC4675_00505)	-	516722..516880 (+)	159	WP_021320463.1	hypothetical protein	-
FGK99_RS10055 (NCTC4675_00506)	-	516894..517040 (+)	147	WP_021320464.1	hypothetical protein	-
FGK99_RS02480 (NCTC4675_00507)	-	517063..517230 (+)	168	WP_138118887.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
FGK99_RS02485 (NCTC4675_00508)	comA	517457..519598 (+)	2142	WP_138118889.1	peptide cleavage/export ABC transporter ComA	Regulator
FGK99_RS02490 (NCTC4675_00509)	comB	519613..520980 (+)	1368	WP_138118891.1	bacteriocin secretion accessory protein	Regulator
FGK99_RS02495 (NCTC4675_00510)	-	521489..521725 (+)	237	WP_024273149.1	hypothetical protein	-
FGK99_RS02500 (NCTC4675_00511)	nrdF	522183..523196 (+)	1014	WP_012678369.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
FGK99_RS02505 (NCTC4675_00512)	nrdI	523198..523608 (+)	411	WP_138119984.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
FGK99_RS02510 (NCTC4675_00513)	nrdE	523654..525828 (+)	2175	WP_138118893.1	class 1b ribonucleoside-diphosphate reductase subunit alpha	-

Sequence

Protein

• Length: 713 a.a.
• Molecular weight: 79996.90 Da
• Isoelectric Point: 9.0945

>NTDB_id=1127168 FGK99_RS02485 WP_138118889.1 517457..519598(+) (comA) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
MKFRRKHYRAQVDTRDCGVASLAMIYGYYGSYYSLATLREAAKTTQEGTTAFGLVKVSEALGFETRAIRADMSLFDVEGL
SYPFIAHVLKKGKFLHYYVVTGQDKKYIHIADPDPTVKLTCLSRQRFASEWTGVTIFIAPTPEYKPHKEKKNSLLDFVPL
LAKQKGLITNIVVATLLVMIINIIGSYYLQSYVPSVMKNTLGIISVGLVIVYALQQVISYAQEYLLLILGQRLSIDVILS
YIKHIFNLPMSFFATRRTGEIVSRFNDANSIIDALASTILSIFLDVSVIVIISLVLFSQNVNLFVISLLALPIYAVIIFA
FMKPFERMNQETMEANSIMSSSIIEDINGIETIKSLTSEKIRYQKIDKEFVAYLKKSFNYSRAESQQRALKKVAQLILNV
SILWIGANLVMDGKMSLGQLTTYNSLLIYFTNPLENIINLQTKLQTAQVANNRLNEVYLVESEFSEKKNVQDLSLTSGDI
KFNDVSYRYGYGKDVLSEINLHIKRGSKVAFVGISGSGKTTLAKMIVSFFEPSKGEISLNNVNLNQIDKHALRQHINYLP
QQPYVFNGTILENLLLGAREGTTQEDIMKAVELAEIKSDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDSPVLI
LDEATSNLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEHVVVLDKGKIIEQGTHRDLVSQNGFCAHLVNS

Nucleotide

• Length: 2142 bp

>NTDB_id=1127168 FGK99_RS02485 WP_138118889.1 517457..519598(+) (comA) [Streptococcus equi subsp. zooepidemicus strain NCTC4675]
ATGAAATTTAGAAGAAAACACTACCGTGCTCAGGTTGATACTCGCGATTGTGGCGTAGCTTCTCTGGCCATGATTTACGG
TTATTATGGATCGTATTATTCGCTAGCAACGTTACGTGAAGCTGCAAAGACAACGCAGGAAGGGACTACAGCTTTTGGTT
TAGTCAAAGTTTCTGAGGCGCTTGGGTTTGAAACGAGAGCTATTAGGGCTGACATGAGTTTATTTGATGTGGAAGGATTA
TCTTATCCTTTTATTGCCCATGTTCTAAAAAAAGGTAAGTTCCTTCATTATTATGTGGTAACAGGACAAGATAAAAAATA
TATTCATATTGCAGATCCAGATCCAACTGTAAAGTTGACTTGTCTTTCTCGTCAGCGATTTGCTTCAGAGTGGACAGGTG
TGACAATTTTTATCGCTCCTACTCCTGAATACAAACCTCACAAGGAAAAGAAAAATAGTCTGCTAGATTTTGTGCCTCTC
CTAGCAAAGCAAAAAGGATTGATTACTAATATCGTTGTGGCAACGCTTTTGGTAATGATTATCAATATTATTGGTTCGTA
TTATCTTCAATCCTATGTTCCTAGTGTGATGAAGAATACACTAGGTATTATTTCCGTAGGTTTGGTTATTGTCTATGCCC
TTCAACAAGTGATCTCATATGCGCAAGAGTATTTATTGCTGATATTAGGGCAACGTTTATCTATTGATGTAATTCTTTCT
TATATCAAACATATTTTCAACCTTCCTATGTCTTTTTTCGCGACGAGAAGGACCGGGGAAATTGTTTCTCGTTTTAATGA
TGCTAATTCAATCATTGATGCTTTAGCAAGTACAATTTTATCTATTTTCCTTGATGTTTCTGTCATTGTAATTATATCTC
TTGTTCTTTTTTCGCAGAATGTAAATCTATTTGTTATCAGTTTGCTTGCTCTGCCTATCTATGCAGTGATTATCTTTGCC
TTCATGAAGCCATTTGAACGGATGAATCAAGAGACAATGGAAGCAAATTCAATCATGTCATCTTCTATTATTGAAGATAT
AAACGGTATTGAGACTATTAAATCATTAACTAGCGAAAAGATAAGATACCAAAAAATAGATAAAGAATTTGTAGCTTATC
TTAAGAAATCTTTCAACTATAGTAGGGCAGAAAGCCAACAACGAGCATTGAAAAAAGTAGCTCAGCTTATCCTAAACGTG
AGCATACTCTGGATAGGAGCCAATCTGGTTATGGACGGAAAAATGAGTTTAGGTCAACTGACTACCTATAACTCTCTCCT
AATCTACTTTACAAATCCTCTGGAGAATATTATCAATCTTCAAACGAAACTTCAAACCGCTCAAGTCGCTAATAATCGAT
TGAATGAGGTATATCTAGTTGAATCCGAGTTCTCTGAAAAGAAGAATGTTCAAGACTTATCTTTGACCTCTGGTGACATA
AAATTCAATGATGTTAGCTATCGATATGGATATGGAAAAGATGTTTTATCAGAAATAAATTTGCATATTAAACGAGGAAG
CAAGGTTGCTTTTGTTGGGATTTCAGGTTCTGGAAAAACGACTTTAGCTAAGATGATTGTCAGTTTCTTTGAACCAAGCA
AAGGCGAAATATCATTAAATAATGTGAATCTAAATCAAATTGACAAACATGCTCTTCGCCAGCACATTAACTATCTTCCT
CAACAACCTTACGTATTTAATGGGACAATCCTTGAGAATTTACTTCTTGGAGCACGTGAAGGGACGACTCAAGAAGACAT
TATGAAGGCAGTAGAATTGGCTGAAATCAAGTCTGATATTGAACGTATGCCTTTGAATTATCAAACAGAGTTAACCTCAG
ATGGTGCAGGGATTTCTGGAGGTCAACGTCAACGTATTGCCTTAGCAAGGGCATTATTGACAGATTCTCCTGTTTTGATA
TTAGACGAAGCTACAAGTAACTTGGATATTTTGACTGAGAAGCGAATTGTTGATAACCTGATGGCTTTAGATAAAACCTT
GATATTTATTGCTCACCGTTTAACTATTGCAGAGCGTACAGAGCATGTCGTCGTTTTGGATAAAGGAAAGATCATAGAGC
AAGGAACACACAGAGACCTTGTTTCTCAGAATGGCTTTTGTGCTCACTTGGTCAATAGTTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (171-434)

• ABC transporter (ABC_tran) (496-646)

• Peptidase C39 family (Peptidase_C39) (6-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	81.172	100	0.816
comA	Streptococcus mitis SK321	80.753	100	0.812
comA	Streptococcus pneumoniae Rx1	80.753	100	0.812
comA	Streptococcus pneumoniae D39	80.753	100	0.812
comA	Streptococcus pneumoniae R6	80.753	100	0.812
comA	Streptococcus pneumoniae TIGR4	80.474	100	0.809
comA	Streptococcus gordonii str. Challis substr. CH1	77.685	100	0.781
comA/nlmT	Streptococcus mutans UA159	62.204	100	0.626