Detailed information NTG1126857

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FGK94_RS01675
• Genome accession: NZ_LR590471
• Coordinates: 367468..368142 (-)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC11854
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 362468..373142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK94_RS01645 (NCTC11854_00347)	-	362653..363846 (-)	1194	WP_024273226.1	lipase	-
FGK94_RS01650 (NCTC11854_00348)	-	363847..364260 (-)	414	WP_037584321.1	hypothetical protein	-
FGK94_RS01655 (NCTC11854_00349)	-	364276..364536 (-)	261	WP_021320716.1	hypothetical protein	-
FGK94_RS01660 (NCTC11854_00350)	-	364533..364913 (-)	381	WP_043029682.1	hypothetical protein	-
FGK94_RS10265 (NCTC11854_00351)	-	365088..365264 (-)	177	WP_195757361.1	hypothetical protein	-
FGK94_RS01665 (NCTC11854_00352)	-	365346..365780 (-)	435	WP_012678015.1	hypothetical protein	-
FGK94_RS01670 (NCTC11854_00353)	ciaH	366165..367475 (-)	1311	WP_012515549.1	sensor histidine kinase	Regulator
FGK94_RS01675 (NCTC11854_00354)	ciaR	367468..368142 (-)	675	WP_012515548.1	response regulator transcription factor	Regulator
FGK94_RS01680 (NCTC11854_00355)	-	368561..371098 (-)	2538	WP_043029677.1	M1 family metallopeptidase	-
FGK94_RS01685 (NCTC11854_00356)	phoU	371332..371985 (-)	654	WP_012678018.1	phosphate signaling complex protein PhoU	-
FGK94_RS01690 (NCTC11854_00357)	pstB	372056..372814 (-)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=1126857 FGK94_RS01675 WP_012515548.1 367468..368142(-) (ciaR) [Streptococcus equi subsp. zooepidemicus strain NCTC11854]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=1126857 FGK94_RS01675 WP_012515548.1 367468..368142(-) (ciaR) [Streptococcus equi subsp. zooepidemicus strain NCTC11854]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAGGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACTAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGTGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATCCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362