Detailed information NTG1126814

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FGK81_RS09460
• Genome accession: NZ_LR590466
• Coordinates: 1818974..1819885 (-)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8193
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1813974..1824885

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK81_RS09440 (NCTC8193_01879)	-	1814985..1816760 (-)	1776	WP_011888527.1	acyltransferase family protein	-
FGK81_RS09445 (NCTC8193_01880)	-	1816757..1817158 (-)	402	WP_011017240.1	MORN repeat-containing protein	-
FGK81_RS09450 (NCTC8193_01881)	-	1817181..1817618 (-)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
FGK81_RS09455 (NCTC8193_01882)	ruvB	1817756..1818754 (-)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
FGK81_RS10080 (NCTC8193_01883)	comS	1818785..1818883 (-)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
FGK81_RS09460 (NCTC8193_01884)	comR	1818974..1819885 (-)	912	WP_011888526.1	helix-turn-helix domain-containing protein	Regulator
FGK81_RS09465 (NCTC8193_01885)	purB	1820016..1821308 (-)	1293	WP_011888525.1	adenylosuccinate lyase	-
FGK81_RS09470 (NCTC8193_01886)	-	1821328..1822746 (-)	1419	WP_011888524.1	hypothetical protein	-
FGK81_RS09475 (NCTC8193_01887)	purK	1822748..1823821 (-)	1074	WP_011888523.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FGK81_RS09480 (NCTC8193_01888)	purE	1823808..1824296 (-)	489	WP_011888522.1	5-(carboxyamino)imidazole ribonucleotide mutase	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=1126814 FGK81_RS09460 WP_011888526.1 1818974..1819885(-) (comR) [Streptococcus pyogenes strain NCTC8193]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=1126814 FGK81_RS09460 WP_011888526.1 1818974..1819885(-) (comR) [Streptococcus pyogenes strain NCTC8193]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366