Detailed information NTG1126542

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: E0F34_RS02740
• Genome accession: NZ_LR536843
• Coordinates: 501607..503760 (-)
• Length: 717 a.a.
• NCBI ID: WP_130885225.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 496607..508760

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F34_RS02710 (SAMEA104035599_00516)	-	496939..497268 (-)	330	WP_000132567.1	hypothetical protein	-
E0F34_RS02715 (SAMEA104035599_00517)	-	497544..497882 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
E0F34_RS02720 (SAMEA104035599_00518)	comE/blpR	497887..498624 (+)	738	WP_001219122.1	response regulator transcription factor	Regulator
E0F34_RS02725 (SAMEA104035599_00519)	-	498638..499978 (+)	1341	WP_001099895.1	sensor histidine kinase	-
E0F34_RS02730 (SAMEA104035599_00520)	blpC	500023..500178 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
E0F34_RS02735 (SAMEA104035599_00521)	-	500235..501596 (-)	1362	WP_001069098.1	bacteriocin secretion accessory protein	-
E0F34_RS02740 (SAMEA104035599_00522)	comA/nlmT	501607..503760 (-)	2154	WP_130885225.1	peptide cleavage/export ABC transporter BlpA	Regulator
E0F34_RS02745 (SAMEA104035599_00523)	blpU	504041..504271 (+)	231	WP_001093268.1	bacteriocin-like peptide BlpU	-
E0F34_RS02750	-	504274..504393 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
E0F34_RS11490 (SAMEA104035599_00524)	-	504690..504854 (+)	165	WP_000727118.1	hypothetical protein	-
E0F34_RS02760 (SAMEA104035599_00525)	-	504851..505255 (+)	405	WP_061649909.1	hypothetical protein	-
E0F34_RS02770 (SAMEA104035599_00526)	-	505884..506267 (+)	384	WP_000877381.1	hypothetical protein	-
E0F34_RS02775 (SAMEA104035599_00527)	-	506319..507008 (+)	690	WP_000760527.1	CPBP family intramembrane glutamic endopeptidase	-
E0F34_RS02780 (SAMEA104035599_00528)	blpZ	507050..507298 (+)	249	WP_000276499.1	immunity protein BlpZ	-
E0F34_RS02785 (SAMEA104035599_00529)	-	507328..507939 (+)	612	WP_000394045.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80722.74 Da
• Isoelectric Point: 7.6796

>NTDB_id=1126542 E0F34_RS02740 WP_130885225.1 501607..503760(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYLLQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQAPENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide

• Length: 2154 bp

>NTDB_id=1126542 E0F34_RS02740 WP_130885225.1 501607..503760(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTT
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTGGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATCTCCTCCAACAAGTCATGAGCTTTTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAGTCTGAGTTCCAAGCCCCAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATTTTGGAAAACTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	71.888	99.721	0.717
comA	Streptococcus mitis NCTC 12261	66.339	99.442	0.66
comA	Streptococcus pneumoniae Rx1	66.059	99.442	0.657
comA	Streptococcus pneumoniae D39	66.059	99.442	0.657
comA	Streptococcus pneumoniae R6	66.059	99.442	0.657
comA	Streptococcus mitis SK321	65.778	99.442	0.654
comA	Streptococcus pneumoniae TIGR4	65.778	99.442	0.654
comA	Streptococcus gordonii str. Challis substr. CH1	65.042	100	0.651