Detailed information NTG1126541

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: E0F34_RS02720
• Genome accession: NZ_LR536843
• Coordinates: 497887..498624 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 492887..503624

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F34_RS02685 (SAMEA104035599_00512)	-	494219..494506 (-)	288	WP_000777760.1	hypothetical protein	-
E0F34_RS02690 (SAMEA104035599_00513)	-	494516..494926 (-)	411	WP_001278301.1	HIT family protein	-
E0F34_RS02695 (SAMEA104035599_00514)	pptA	494994..495725 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
E0F34_RS02700 (SAMEA104035599_00515)	-	495722..496771 (+)	1050	WP_000653773.1	ABC transporter permease	-
E0F34_RS02710 (SAMEA104035599_00516)	-	496939..497268 (-)	330	WP_000132567.1	hypothetical protein	-
E0F34_RS02715 (SAMEA104035599_00517)	-	497544..497882 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
E0F34_RS02720 (SAMEA104035599_00518)	comE/blpR	497887..498624 (+)	738	WP_001219122.1	response regulator transcription factor	Regulator
E0F34_RS02725 (SAMEA104035599_00519)	-	498638..499978 (+)	1341	WP_001099895.1	sensor histidine kinase	-
E0F34_RS02730 (SAMEA104035599_00520)	blpC	500023..500178 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
E0F34_RS02735 (SAMEA104035599_00521)	-	500235..501596 (-)	1362	WP_001069098.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=1126541 E0F34_RS02720 WP_001219122.1 497887..498624(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1126541 E0F34_RS02720 WP_001219122.1 497887..498624(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38