Detailed information NTG1126341

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: E0F40_RS05865
• Genome accession: NZ_LR216065
• Coordinates: 1106156..1106860 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1101156..1111860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F40_RS05835 (SAMEA3714487_01113)	-	1101469..1102455 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
E0F40_RS05840 (SAMEA3714487_01114)	-	1102715..1103367 (-)	653	Protein_1112	potassium channel family protein	-
E0F40_RS05845 (SAMEA3714487_01115)	-	1103414..1103668 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE family toxin	-
E0F40_RS05850 (SAMEA3714487_01116)	relB	1103670..1103912 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F40_RS05855 (SAMEA3714487_01117)	vicX	1104003..1104812 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F40_RS05860 (SAMEA3714487_01118)	micB	1104814..1106163 (-)	1350	WP_000886209.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F40_RS05865 (SAMEA3714487_01119)	micA	1106156..1106860 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F40_RS05870 (SAMEA3714487_01120)	mutY	1106915..1108090 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
E0F40_RS05880 (SAMEA3714487_01121)	-	1108419..1110089 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
E0F40_RS05885 (SAMEA3714487_01122)	coaB	1110319..1111008 (+)	690	WP_000699488.1	phosphopantothenate--cysteine ligase	-
E0F40_RS05890 (SAMEA3714487_01123)	coaC	1111020..1111571 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1126341 E0F40_RS05865 WP_000722076.1 1106156..1106860(-) (micA) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1126341 E0F40_RS05865 WP_000722076.1 1106156..1106860(-) (micA) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38