Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   E0F40_RS02500 Genome accession   NZ_LR216065
Coordinates   454693..456846 (-) Length   717 a.a.
NCBI ID   WP_000205153.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 449693..461846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F40_RS02470 (SAMEA3714487_00450) - 450024..450353 (-) 330 WP_000132572.1 hypothetical protein -
  E0F40_RS02475 (SAMEA3714487_00451) - 450630..450968 (+) 339 WP_000682132.1 LytTR family DNA-binding domain-containing protein -
  E0F40_RS02480 (SAMEA3714487_00452) comE/blpR 450973..451710 (+) 738 WP_001219146.1 response regulator transcription factor Regulator
  E0F40_RS02485 (SAMEA3714487_00453) - 451724..453064 (+) 1341 WP_001099895.1 sensor histidine kinase -
  E0F40_RS02490 (SAMEA3714487_00454) blpC 453109..453264 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  E0F40_RS02495 (SAMEA3714487_00455) - 453321..454682 (-) 1362 WP_001069098.1 bacteriocin secretion accessory protein -
  E0F40_RS02500 (SAMEA3714487_00456) comA/nlmT 454693..456846 (-) 2154 WP_000205153.1 peptide cleavage/export ABC transporter BlpA Regulator
  E0F40_RS02505 (SAMEA3714487_00457) blpU 457127..457357 (+) 231 WP_001093268.1 bacteriocin-like peptide BlpU -
  E0F40_RS02510 - 457360..457479 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  E0F40_RS11705 (SAMEA3714487_00458) - 457776..457940 (+) 165 WP_000727118.1 hypothetical protein -
  E0F40_RS02520 (SAMEA3714487_00459) - 457937..458341 (+) 405 WP_000846944.1 hypothetical protein -
  E0F40_RS02525 - 458539..459344 (+) 806 Protein_471 IS5 family transposase -
  E0F40_RS02530 (SAMEA3714487_00462) blpM 459546..459800 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  E0F40_RS02535 (SAMEA3714487_00463) blpN 459816..460019 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  E0F40_RS02545 (SAMEA3714487_00464) cipB 460263..460412 (+) 150 WP_001813641.1 bacteriocin-like peptide BlpO Regulator
  E0F40_RS02550 - 460516..460635 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -
  E0F40_RS02560 (SAMEA3714487_00465) - 461421..461804 (+) 384 WP_000877378.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80791.85 Da        Isoelectric Point: 7.9869

>NTDB_id=1126327 E0F40_RS02500 WP_000205153.1 454693..456846(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSRLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQAPENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1126327 E0F40_RS02500 WP_000205153.1 454693..456846(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGATTATTGGTCACTATTATCAATATCGGTGGTTCTTA
CTATCTCCAAGGAATCTTGGATGAATACATTCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAGTCTGAGTTCCAAGCCCCAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATTTTGGAAAACTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.888

99.721

0.717
  comA Streptococcus mitis NCTC 12261

66.48

99.442

0.661
  comA Streptococcus pneumoniae Rx1

66.199

99.442

0.658
  comA Streptococcus pneumoniae D39

66.199

99.442

0.658
  comA Streptococcus pneumoniae R6

66.199

99.442

0.658
  comA Streptococcus mitis SK321

65.919

99.442

0.656
  comA Streptococcus pneumoniae TIGR4

65.919

99.442

0.656
  comA Streptococcus gordonii str. Challis substr. CH1

65.181

100

0.653

Multiple sequence alignment