Detailed information NTG1126326

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: E0F40_RS02480
• Genome accession: NZ_LR216065
• Coordinates: 450973..451710 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219146.1
• Uniprot ID: A0A1C0UQ30
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 445973..456710

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F40_RS11615	-	446903..447142 (-)	240	WP_001813906.1	hypothetical protein	-
E0F40_RS02450 (SAMEA3714487_00446)	-	447304..447591 (-)	288	WP_000777760.1	hypothetical protein	-
E0F40_RS02455 (SAMEA3714487_00447)	-	447601..448011 (-)	411	WP_001278301.1	HIT family protein	-
E0F40_RS02460 (SAMEA3714487_00448)	pptA	448079..448810 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
E0F40_RS02465 (SAMEA3714487_00449)	-	448807..449856 (+)	1050	WP_000653771.1	ABC transporter permease	-
E0F40_RS02470 (SAMEA3714487_00450)	-	450024..450353 (-)	330	WP_000132572.1	hypothetical protein	-
E0F40_RS02475 (SAMEA3714487_00451)	-	450630..450968 (+)	339	WP_000682132.1	LytTR family DNA-binding domain-containing protein	-
E0F40_RS02480 (SAMEA3714487_00452)	comE/blpR	450973..451710 (+)	738	WP_001219146.1	response regulator transcription factor	Regulator
E0F40_RS02485 (SAMEA3714487_00453)	-	451724..453064 (+)	1341	WP_001099895.1	sensor histidine kinase	-
E0F40_RS02490 (SAMEA3714487_00454)	blpC	453109..453264 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
E0F40_RS02495 (SAMEA3714487_00455)	-	453321..454682 (-)	1362	WP_001069098.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.87 Da
• Isoelectric Point: 6.0454

>NTDB_id=1126326 E0F40_RS02480 WP_001219146.1 450973..451710(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1126326 E0F40_RS02480 WP_001219146.1 450973..451710(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A1C0UQ30

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363