Detailed information NTG1126265

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: E0F31_RS05855
• Genome accession: NZ_LR216064
• Coordinates: 1104321..1105025 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1099321..1110025

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F31_RS05825 (SAMEA3714520_01090)	-	1099510..1100496 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
E0F31_RS05830 (SAMEA3714520_01091)	-	1100759..1101532 (-)	774	WP_000725951.1	potassium channel family protein	-
E0F31_RS05835 (SAMEA3714520_01092)	-	1101579..1101833 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
E0F31_RS05840 (SAMEA3714520_01093)	relB	1101835..1102077 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F31_RS05845 (SAMEA3714520_01094)	vicX	1102168..1102977 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F31_RS05850 (SAMEA3714520_01095)	micB	1102979..1104328 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F31_RS05855 (SAMEA3714520_01096)	micA	1104321..1105025 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F31_RS05860 (SAMEA3714520_01097)	mutY	1105080..1106255 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
E0F31_RS12070	-	1106352..1106477 (+)	126	WP_001818232.1	hypothetical protein	-
E0F31_RS05865 (SAMEA3714520_01098)	-	1106583..1108253 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
E0F31_RS05870 (SAMEA3714520_01099)	coaB	1108483..1109172 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
E0F31_RS05875 (SAMEA3714520_01100)	coaC	1109184..1109735 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1126265 E0F31_RS05855 WP_000722076.1 1104321..1105025(-) (micA) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1126265 E0F31_RS05855 WP_000722076.1 1104321..1105025(-) (micA) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38