Detailed information NTG1126264

Bioinformatically predicted

Overview

• Name: micB
• Type: Regulator
• Locus tag: E0F31_RS05850
• Genome accession: NZ_LR216064
• Coordinates: 1102979..1104328 (-)
• Length: 449 a.a.
• NCBI ID: WP_000886210.1
• Uniprot ID: A0A064BZM9
• Organism: Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1097979..1109328

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F31_RS05825 (SAMEA3714520_01090)	-	1099510..1100496 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
E0F31_RS05830 (SAMEA3714520_01091)	-	1100759..1101532 (-)	774	WP_000725951.1	potassium channel family protein	-
E0F31_RS05835 (SAMEA3714520_01092)	-	1101579..1101833 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
E0F31_RS05840 (SAMEA3714520_01093)	relB	1101835..1102077 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F31_RS05845 (SAMEA3714520_01094)	vicX	1102168..1102977 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F31_RS05850 (SAMEA3714520_01095)	micB	1102979..1104328 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F31_RS05855 (SAMEA3714520_01096)	micA	1104321..1105025 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F31_RS05860 (SAMEA3714520_01097)	mutY	1105080..1106255 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
E0F31_RS12070	-	1106352..1106477 (+)	126	WP_001818232.1	hypothetical protein	-
E0F31_RS05865 (SAMEA3714520_01098)	-	1106583..1108253 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
E0F31_RS05870 (SAMEA3714520_01099)	coaB	1108483..1109172 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51712.42 Da
• Isoelectric Point: 4.9706

>NTDB_id=1126264 E0F31_RS05850 WP_000886210.1 1102979..1104328(-) (micB) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide

• Length: 1350 bp

>NTDB_id=1126264 E0F31_RS05850 WP_000886210.1 1102979..1104328(-) (micB) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACTAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAAACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCATCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

• PAS fold (PAS) (98-198)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (324-434)

3D structure

• AlphaFold DB: A0A064BZM9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micB	Streptococcus pneumoniae Cp1015	99.777	100	0.998
vicK	Streptococcus mutans UA159	69.9	89.532	0.626