Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   E0F31_RS02605 Genome accession   NZ_LR216064
Coordinates   482273..484426 (-) Length   717 a.a.
NCBI ID   WP_000205150.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 477273..489426
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS02575 (SAMEA3714520_00477) - 477604..477933 (-) 330 WP_000132572.1 hypothetical protein -
  E0F31_RS02580 (SAMEA3714520_00478) - 478210..478548 (+) 339 WP_000682134.1 LytTR family DNA-binding domain-containing protein -
  E0F31_RS02585 (SAMEA3714520_00479) comE/blpR 478553..479290 (+) 738 WP_001219146.1 response regulator transcription factor Regulator
  E0F31_RS02590 (SAMEA3714520_00480) - 479304..480644 (+) 1341 WP_001099895.1 sensor histidine kinase -
  E0F31_RS02595 (SAMEA3714520_00481) blpC 480689..480844 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  E0F31_RS02600 (SAMEA3714520_00482) - 480901..482262 (-) 1362 WP_001069078.1 bacteriocin secretion accessory protein -
  E0F31_RS02605 (SAMEA3714520_00483) comA/nlmT 482273..484426 (-) 2154 WP_000205150.1 peptide cleavage/export ABC transporter BlpA Regulator
  E0F31_RS02610 (SAMEA3714520_00484) - 484706..484909 (+) 204 WP_001093262.1 bacteriocin class II family protein -
  E0F31_RS02615 (SAMEA3714520_00485) - 485227..485430 (+) 204 WP_000411016.1 hypothetical protein -
  E0F31_RS02625 - 486433..487194 (+) 762 Protein_501 transposase -
  E0F31_RS02630 (SAMEA3714520_00489) blpM 487344..487598 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  E0F31_RS02635 (SAMEA3714520_00490) blpN 487614..487817 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  E0F31_RS02645 cipB 488061..488210 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator
  E0F31_RS02650 - 488314..488433 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80801.77 Da        Isoelectric Point: 7.6798

>NTDB_id=1126251 E0F31_RS02605 WP_000205150.1 482273..484426(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMGDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISTGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1126251 E0F31_RS02605 WP_000205150.1 482273..484426(-) (comA/nlmT) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACGCTCTTTGACATGGGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGAGTCTTGCTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTACCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTCG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTCCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCACAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACTTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGACGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(169-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.888

99.721

0.717
  comA Streptococcus mitis NCTC 12261

66.48

99.442

0.661
  comA Streptococcus pneumoniae Rx1

65.919

99.442

0.656
  comA Streptococcus pneumoniae R6

65.919

99.442

0.656
  comA Streptococcus pneumoniae D39

65.919

99.442

0.656
  comA Streptococcus mitis SK321

65.919

99.442

0.656
  comA Streptococcus gordonii str. Challis substr. CH1

65.181

100

0.653
  comA Streptococcus pneumoniae TIGR4

65.638

99.442

0.653

Multiple sequence alignment