Detailed information NTG1126250

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: E0F31_RS02585
• Genome accession: NZ_LR216064
• Coordinates: 478553..479290 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219146.1
• Uniprot ID: A0A1C0UQ30
• Organism: Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 473553..484290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F31_RS11325 (SAMEA3714520_00472)	-	474483..474722 (-)	240	WP_001813906.1	hypothetical protein	-
E0F31_RS02555 (SAMEA3714520_00473)	-	474884..475171 (-)	288	WP_000777760.1	hypothetical protein	-
E0F31_RS02560 (SAMEA3714520_00474)	-	475181..475591 (-)	411	WP_001278301.1	HIT family protein	-
E0F31_RS02565 (SAMEA3714520_00475)	pptA	475659..476390 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
E0F31_RS02570 (SAMEA3714520_00476)	-	476387..477436 (+)	1050	WP_000653770.1	ABC transporter permease	-
E0F31_RS02575 (SAMEA3714520_00477)	-	477604..477933 (-)	330	WP_000132572.1	hypothetical protein	-
E0F31_RS02580 (SAMEA3714520_00478)	-	478210..478548 (+)	339	WP_000682134.1	LytTR family DNA-binding domain-containing protein	-
E0F31_RS02585 (SAMEA3714520_00479)	comE/blpR	478553..479290 (+)	738	WP_001219146.1	response regulator transcription factor	Regulator
E0F31_RS02590 (SAMEA3714520_00480)	-	479304..480644 (+)	1341	WP_001099895.1	sensor histidine kinase	-
E0F31_RS02595 (SAMEA3714520_00481)	blpC	480689..480844 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
E0F31_RS02600 (SAMEA3714520_00482)	-	480901..482262 (-)	1362	WP_001069078.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.87 Da
• Isoelectric Point: 6.0454

>NTDB_id=1126250 E0F31_RS02585 WP_001219146.1 478553..479290(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1126250 E0F31_RS02585 WP_001219146.1 478553..479290(+) (comE/blpR) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A1C0UQ30

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363