Detailed information NTG1126114

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: E0F32_RS06035
• Genome accession: NZ_LR216050
• Coordinates: 1133974..1134678 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1128974..1139678

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F32_RS06010 (SAMEA3431333_01122)	-	1129271..1131157 (-)	1887	WP_000150984.1	Eco57I restriction-modification methylase domain-containing protein	-
E0F32_RS06015 (SAMEA3431333_01123)	-	1131232..1131486 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
E0F32_RS06020 (SAMEA3431333_01124)	relB	1131488..1131730 (-)	243	WP_024477795.1	type II toxin-antitoxin system RelB family antitoxin	-
E0F32_RS06025 (SAMEA3431333_01125)	vicX	1131821..1132630 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
E0F32_RS06030 (SAMEA3431333_01126)	micB	1132632..1133981 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
E0F32_RS06035 (SAMEA3431333_01127)	micA	1133974..1134678 (-)	705	WP_000722076.1	response regulator YycF	Regulator
E0F32_RS06040 (SAMEA3431333_01128)	mutY	1134733..1135908 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
E0F32_RS12160	-	1136005..1136130 (+)	126	WP_001818232.1	hypothetical protein	-
E0F32_RS06045 (SAMEA3431333_01129)	-	1136236..1137906 (-)	1671	WP_024477796.1	formate--tetrahydrofolate ligase	-
E0F32_RS06050 (SAMEA3431333_01130)	coaB	1138136..1138825 (+)	690	WP_000699488.1	phosphopantothenate--cysteine ligase	-
E0F32_RS06055 (SAMEA3431333_01131)	coaC	1138837..1139388 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1126114 E0F32_RS06035 WP_000722076.1 1133974..1134678(-) (micA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1126114 E0F32_RS06035 WP_000722076.1 1133974..1134678(-) (micA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38