Detailed information NTG1126100

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: E0F32_RS02540
• Genome accession: NZ_LR216050
• Coordinates: 451053..451790 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 446053..456790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F32_RS02520 (SAMEA3431333_00466)	comA/nlmT	446428..448071 (+)	1644	WP_078133412.1	peptide cleavage/export ABC transporter	Regulator
E0F32_RS02525 (SAMEA3431333_00467)	-	448082..449443 (+)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
E0F32_RS02530 (SAMEA3431333_00468)	blpC	449500..449628 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
E0F32_RS02535 (SAMEA3431333_00469)	-	449699..451039 (-)	1341	WP_001017642.1	sensor histidine kinase	-
E0F32_RS02540 (SAMEA3431333_00470)	comE/blpR	451053..451790 (-)	738	WP_001219120.1	response regulator transcription factor	Regulator
E0F32_RS02545 (SAMEA3431333_00471)	-	451795..452133 (-)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
E0F32_RS02550 (SAMEA3431333_00472)	-	452409..452738 (+)	330	WP_000132572.1	hypothetical protein	-
E0F32_RS02560 (SAMEA3431333_00473)	-	452906..453955 (-)	1050	WP_000653771.1	ABC transporter permease	-
E0F32_RS02565 (SAMEA3431333_00474)	pptA	453952..454683 (-)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
E0F32_RS02570 (SAMEA3431333_00475)	-	454751..455161 (+)	411	WP_001278301.1	HIT family protein	-
E0F32_RS02575 (SAMEA3431333_00476)	-	455171..455458 (+)	288	WP_000777753.1	hypothetical protein	-
E0F32_RS02580	-	455620..455814 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=1126100 E0F32_RS02540 WP_001219120.1 451053..451790(-) (comE/blpR) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=1126100 E0F32_RS02540 WP_001219120.1 451053..451790(-) (comE/blpR) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363