Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EL267_RS05940 Genome accession   NZ_LR134520
Coordinates   1135004..1135684 (+) Length   226 a.a.
NCBI ID   WP_000590620.1    Uniprot ID   A0AAV3JNX7
Organism   Streptococcus agalactiae strain NCTC13947     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1130004..1140684
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL267_RS05925 (NCTC13947_01168) pstB 1130702..1131460 (+) 759 WP_000193363.1 phosphate ABC transporter ATP-binding protein PstB -
  EL267_RS05930 (NCTC13947_01169) phoU 1131494..1132147 (+) 654 WP_000946330.1 phosphate signaling complex protein PhoU -
  EL267_RS05935 (NCTC13947_01170) - 1132293..1134842 (+) 2550 WP_121205169.1 M1 family metallopeptidase -
  EL267_RS05940 (NCTC13947_01171) ciaR 1135004..1135684 (+) 681 WP_000590620.1 response regulator transcription factor Regulator
  EL267_RS05945 (NCTC13947_01172) ciaH 1135668..1136981 (+) 1314 WP_000042576.1 sensor histidine kinase Regulator
  EL267_RS05950 (NCTC13947_01173) - 1137070..1137402 (+) 333 WP_000402075.1 putative DNA-binding protein -
  EL267_RS05955 (NCTC13947_01174) ffh 1137420..1138985 (+) 1566 WP_000863593.1 signal recognition particle protein -
  EL267_RS05960 (NCTC13947_01175) - 1139052..1139738 (+) 687 WP_000280304.1 SatD family protein -
  EL267_RS05965 (NCTC13947_01176) - 1139728..1140501 (+) 774 WP_000622396.1 DUF3307 domain-containing protein -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25852.63 Da        Isoelectric Point: 4.2507

>NTDB_id=1123808 EL267_RS05940 WP_000590620.1 1135004..1135684(+) (ciaR) [Streptococcus agalactiae strain NCTC13947]
MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD

Nucleotide


Download         Length: 681 bp        

>NTDB_id=1123808 EL267_RS05940 WP_000590620.1 1135004..1135684(+) (ciaR) [Streptococcus agalactiae strain NCTC13947]
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTCCTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTTTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTCTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae D39

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae R6

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae Rx1

88.393

99.115

0.876
  ciaR Streptococcus mutans UA159

88.688

97.788

0.867
  vicR Streptococcus mutans UA159

35.193

100

0.363
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.607

99.115

0.363

Multiple sequence alignment