Detailed information NTG1121437

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EL130_RS07205
• Genome accession: NZ_LR134320
• Coordinates: 1436812..1437486 (-)
• Length: 224 a.a.
• NCBI ID: WP_002264509.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain NCTC10832
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1431812..1442486

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL130_RS07180 (NCTC10832_01383)	-	1432120..1433397 (-)	1278	WP_002274222.1	pyrimidine-nucleoside phosphorylase	-
EL130_RS07185 (NCTC10832_01384)	-	1433506..1434102 (-)	597	WP_126475489.1	class I SAM-dependent methyltransferase	-
EL130_RS07190 (NCTC10832_01385)	coaA	1434198..1435118 (+)	921	WP_019320028.1	type I pantothenate kinase	-
EL130_RS07195 (NCTC10832_01386)	rpsT	1435172..1435426 (+)	255	WP_011074586.1	30S ribosomal protein S20	-
EL130_RS07200 (NCTC10832_01387)	ciaH	1435515..1436822 (-)	1308	WP_002302496.1	three-component system sensor histidine kinase CiaH	Regulator
EL130_RS07205 (NCTC10832_01388)	ciaR	1436812..1437486 (-)	675	WP_002264509.1	three-component system response regulator CiaR	Regulator
EL130_RS07210 (NCTC10832_01389)	ciaX	1437537..1437800 (-)	264	WP_002274220.1	three-component system regulator CiaX	-
EL130_RS07215 (NCTC10832_01391)	-	1438201..1440750 (-)	2550	WP_126475490.1	M1 family metallopeptidase	-
EL130_RS07220 (NCTC10832_01392)	phoU	1440791..1441444 (-)	654	WP_002262211.1	phosphate signaling complex protein PhoU	-
EL130_RS07225 (NCTC10832_01393)	pstB	1441476..1442234 (-)	759	WP_002262210.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25417.19 Da
• Isoelectric Point: 4.3777

>NTDB_id=1121437 EL130_RS07205 WP_002264509.1 1436812..1437486(-) (ciaR) [Streptococcus mutans strain NCTC10832]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide

• Length: 675 bp

>NTDB_id=1121437 EL130_RS07205 WP_002264509.1 1436812..1437486(-) (ciaR) [Streptococcus mutans strain NCTC10832]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	99.554	100	0.996
ciaR	Streptococcus pneumoniae Rx1	87.946	100	0.879
ciaR	Streptococcus pneumoniae D39	87.946	100	0.879
ciaR	Streptococcus pneumoniae R6	87.946	100	0.879
ciaR	Streptococcus pneumoniae TIGR4	87.946	100	0.879
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.379
vicR	Streptococcus mutans UA159	35.622	100	0.371