Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL130_RS07200 Genome accession   NZ_LR134320
Coordinates   1435515..1436822 (-) Length   435 a.a.
NCBI ID   WP_002302496.1    Uniprot ID   -
Organism   Streptococcus mutans strain NCTC10832     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1430515..1441822
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL130_RS07170 (NCTC10832_01381) - 1431063..1431533 (-) 471 WP_012997758.1 cytidine deaminase -
  EL130_RS07175 (NCTC10832_01382) deoC 1431439..1432101 (-) 663 WP_002262220.1 deoxyribose-phosphate aldolase -
  EL130_RS07180 (NCTC10832_01383) - 1432120..1433397 (-) 1278 WP_002274222.1 pyrimidine-nucleoside phosphorylase -
  EL130_RS07185 (NCTC10832_01384) - 1433506..1434102 (-) 597 WP_126475489.1 class I SAM-dependent methyltransferase -
  EL130_RS07190 (NCTC10832_01385) coaA 1434198..1435118 (+) 921 WP_019320028.1 type I pantothenate kinase -
  EL130_RS07195 (NCTC10832_01386) rpsT 1435172..1435426 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  EL130_RS07200 (NCTC10832_01387) ciaH 1435515..1436822 (-) 1308 WP_002302496.1 three-component system sensor histidine kinase CiaH Regulator
  EL130_RS07205 (NCTC10832_01388) ciaR 1436812..1437486 (-) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  EL130_RS07210 (NCTC10832_01389) ciaX 1437537..1437800 (-) 264 WP_002274220.1 three-component system regulator CiaX -
  EL130_RS07215 (NCTC10832_01391) - 1438201..1440750 (-) 2550 WP_126475490.1 M1 family metallopeptidase -
  EL130_RS07220 (NCTC10832_01392) phoU 1440791..1441444 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49826.27 Da        Isoelectric Point: 9.7262

>NTDB_id=1121436 EL130_RS07200 WP_002302496.1 1435515..1436822(-) (ciaH) [Streptococcus mutans strain NCTC10832]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEIAEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=1121436 EL130_RS07200 WP_002302496.1 1435515..1436822(-) (ciaH) [Streptococcus mutans strain NCTC10832]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAGCAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAG
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAGAAAATTTTTGATCGTTTTTATCGCGTTGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.54

100

0.995
  ciaH Streptococcus pneumoniae Rx1

55.862

100

0.559
  ciaH Streptococcus pneumoniae D39

55.862

100

0.559
  ciaH Streptococcus pneumoniae R6

55.862

100

0.559
  ciaH Streptococcus pneumoniae TIGR4

55.862

100

0.559

Multiple sequence alignment