Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   EL136_RS00985 Genome accession   NZ_LR134317
Coordinates   189957..192113 (-) Length   718 a.a.
NCBI ID   WP_154803614.1    Uniprot ID   A0A7Z8ZU23
Organism   Streptococcus equi subsp. zooepidemicus strain NCTC6180     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 184957..197113
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL136_RS00955 (NCTC6180_00196) - 185050..185307 (+) 258 WP_043030068.1 Blp family class II bacteriocin -
  EL136_RS00960 (NCTC6180_00197) - 185324..185518 (+) 195 WP_038674052.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  EL136_RS00965 (NCTC6180_00198) comE/blpR 186152..186901 (+) 750 WP_111690344.1 LytR/AlgR family response regulator transcription factor Regulator
  EL136_RS00970 (NCTC6180_00199) - 186901..188235 (+) 1335 WP_154803611.1 sensor histidine kinase -
  EL136_RS00975 (NCTC6180_00200) - 188357..188488 (-) 132 WP_154803612.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EL136_RS00980 (NCTC6180_00201) - 188588..189946 (-) 1359 WP_154803613.1 bacteriocin secretion accessory protein -
  EL136_RS00985 (NCTC6180_00202) comA/nlmT 189957..192113 (-) 2157 WP_154803614.1 peptide cleavage/export ABC transporter Regulator
  EL136_RS00990 (NCTC6180_00203) - 192372..192590 (+) 219 WP_154803615.1 Blp family class II bacteriocin -
  EL136_RS00995 (NCTC6180_00204) - 192590..192886 (+) 297 WP_043040989.1 bacteriocin immunity protein -
  EL136_RS01000 (NCTC6180_00205) - 193039..193287 (+) 249 WP_154803616.1 garvicin Q family class II bacteriocin -
  EL136_RS01005 (NCTC6180_00206) - 193294..193593 (+) 300 WP_043030073.1 bacteriocin immunity protein -
  EL136_RS01010 (NCTC6180_00207) - 194331..194585 (+) 255 WP_043053342.1 Blp family class II bacteriocin -
  EL136_RS01015 (NCTC6180_00208) - 194602..194805 (+) 204 WP_012516109.1 Blp family class II bacteriocin -
  EL136_RS01020 (NCTC6180_00209) - 195479..195880 (+) 402 WP_232013920.1 bacteriocin immunity protein -
  EL136_RS01025 (NCTC6180_00210) - 196140..196721 (+) 582 WP_111690338.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 718 a.a.        Molecular weight: 80651.83 Da        Isoelectric Point: 7.7847

>NTDB_id=1121258 EL136_RS00985 WP_154803614.1 189957..192113(-) (comA/nlmT) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MTLFYKRTFVPQIDARDCGVAALASIARYYGSDYSLAHLRELAKTNKEGTTALGIVMAAKEMGFETRPIQADMTLFDMAD
VPYPLIVHVNKEGKLQHYYVVYKSKKDYLIIGDPDPMVKVTKMSKERFASEWTGVTICLAPKPNYKPHKDQKNGLLGFFP
LIFKQRALIFYIVLASVLVTVINIAGSYYLQGILDEYIPNQLKSTLGIVSIGLIITYILQQLMSFSRDYLLTVLSQRLTI
DVILSYIRHIFELPMSFFATRRTGEVTSRFTDANSIIDALASTILSLFLDLSILAIVGSVLLVQNSRLFLLSLISIPVYT
IIICAFIKPFEQMNHDVMQSNAMLSSAIIEDINGIETIKSLTSEENRYQKIDSDFVDYLDKSFRLSKYTILQATLKQGAQ
LILNIIILWFGAQLVINGRISIGQLITFNTLLAYFTTPLENIINLQTKLQAAKVANNRLNEVYLVESEFKASQALYDLSL
LQGDIQFEAVSYRYGFGKDTLSDITLTIKQGAKVTLVGVSGSGKTTLAKMLVNFFEPYKGRITINQNDLKTIDKKNLRQY
INYLPQQAYIFNGSILENLTLGAKQGISQEDILKACEIADIRHDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTQA
PILVFDEATSGLDILTEKKIIDRLMNMTDKTIIFVAHRLSIAERTDQVVVLNQGQIIETGSHQELMKQGGFYYHLFSE

Nucleotide


Download         Length: 2157 bp        

>NTDB_id=1121258 EL136_RS00985 WP_154803614.1 189957..192113(-) (comA/nlmT) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGACACTCTTTTATAAAAGAACCTTTGTACCACAAATAGATGCCAGAGATTGTGGCGTAGCTGCTCTAGCTTCGATCGC
AAGGTATTATGGTTCAGATTATTCATTAGCTCATTTGAGAGAATTAGCAAAGACCAATAAGGAAGGGACAACAGCCCTCG
GTATTGTCATGGCTGCTAAGGAAATGGGATTTGAAACCAGACCCATTCAAGCGGATATGACCCTCTTTGACATGGCAGAC
GTGCCCTATCCATTGATCGTCCATGTCAATAAAGAAGGAAAGCTACAGCACTACTATGTGGTCTACAAATCTAAAAAAGA
CTATCTTATCATTGGTGATCCCGATCCAATGGTCAAGGTCACAAAAATGTCCAAGGAACGCTTTGCTTCTGAATGGACAG
GTGTCACCATATGTCTTGCTCCTAAGCCAAATTATAAACCACATAAAGACCAAAAAAATGGACTATTAGGCTTCTTTCCG
CTTATTTTTAAACAGCGAGCCCTTATTTTTTATATCGTGTTAGCTTCTGTCTTGGTAACAGTCATTAATATTGCTGGTTC
ATACTATCTCCAAGGGATTTTAGACGAGTATATTCCAAATCAGCTGAAATCTACCTTAGGGATTGTATCAATTGGTCTCA
TCATTACCTATATACTCCAGCAGCTAATGAGCTTTTCTAGAGATTATCTTTTAACTGTCCTTAGCCAACGTCTTACGATT
GATGTGATCCTGTCCTATATCCGCCATATTTTCGAATTGCCGATGTCCTTTTTTGCAACACGTCGAACAGGTGAGGTAAC
CTCGCGCTTTACAGATGCTAACTCTATCATTGACGCACTCGCTTCAACCATTTTATCCCTCTTTCTAGACCTCTCTATAT
TAGCTATTGTCGGAAGTGTTCTTTTGGTGCAAAATAGCAGGCTTTTTCTGCTATCTCTGATTTCTATCCCAGTATATACC
ATTATCATATGTGCCTTTATAAAGCCGTTTGAACAAATGAATCATGATGTGATGCAAAGCAATGCTATGCTAAGCTCTGC
TATTATCGAAGATATCAACGGGATCGAAACCATAAAATCACTAACCAGTGAAGAAAACCGTTACCAAAAAATTGACAGCG
ACTTTGTGGATTACCTCGATAAGTCCTTTAGGCTTAGTAAATATACCATCTTACAAGCCACACTTAAGCAAGGAGCGCAG
CTAATTCTGAATATCATCATTCTTTGGTTTGGGGCTCAACTGGTTATTAATGGTAGGATTTCAATTGGGCAGTTAATTAC
CTTTAACACACTTCTTGCCTATTTTACAACCCCTTTAGAAAATATCATTAATCTTCAAACTAAGCTCCAAGCAGCTAAGG
TTGCCAACAATCGTCTCAATGAGGTCTATCTTGTAGAGTCCGAATTTAAAGCCTCGCAAGCCTTATACGATTTATCGCTC
TTACAGGGTGACATTCAGTTTGAAGCTGTTTCCTACAGGTATGGCTTTGGCAAGGATACATTATCAGATATTACATTAAC
CATTAAGCAGGGAGCAAAAGTAACCCTTGTTGGTGTCAGCGGCTCAGGAAAAACAACCCTAGCCAAGATGCTCGTCAATT
TCTTTGAACCTTATAAGGGACGTATAACCATCAACCAAAACGATCTCAAGACCATTGATAAAAAGAATCTTCGACAATAC
ATCAACTACCTTCCACAACAAGCCTATATCTTTAATGGATCTATCTTAGAAAATCTAACCTTGGGAGCCAAGCAAGGCAT
CAGCCAGGAAGACATTCTTAAAGCCTGTGAGATTGCTGACATTCGTCACGACATCGAGCAAATGCCAATGGGATACCAAA
CCGAGCTCTCTGATGGAGCTGGCTTATCTGGCGGACAAAAACAGAGAATTGCACTTGCTAGAGCATTACTAACCCAAGCT
CCTATACTAGTTTTTGATGAAGCAACCAGCGGACTTGACATACTGACAGAAAAGAAAATCATTGACCGTCTCATGAACAT
GACAGACAAAACGATTATTTTCGTTGCCCACCGGCTTAGTATCGCAGAGCGCACTGATCAGGTTGTGGTTCTTAATCAAG
GGCAAATCATTGAAACAGGCAGCCACCAGGAATTAATGAAACAAGGTGGATTTTATTACCACCTATTTAGTGAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-439)

Peptidase C39 family (Peptidase_C39)

(8-143)

ABC transporter (ABC_tran)

(501-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7Z8ZU23

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

70.711

99.861

0.706
  comA Streptococcus mitis SK321

67.461

99.304

0.67
  comA Streptococcus mitis NCTC 12261

67.181

99.304

0.667
  comA Streptococcus pneumoniae Rx1

66.76

99.304

0.663
  comA Streptococcus pneumoniae D39

66.76

99.304

0.663
  comA Streptococcus pneumoniae R6

66.76

99.304

0.663
  comA Streptococcus pneumoniae TIGR4

66.48

99.304

0.66
  comA Streptococcus gordonii str. Challis substr. CH1

65.077

99.304

0.646

Multiple sequence alignment