Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EL136_RS00965 Genome accession   NZ_LR134317
Coordinates   186152..186901 (+) Length   249 a.a.
NCBI ID   WP_111690344.1    Uniprot ID   -
Organism   Streptococcus equi subsp. zooepidemicus strain NCTC6180     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 181152..191901
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL136_RS00940 (NCTC6180_00193) recX 181557..182333 (-) 777 WP_154803609.1 recombination regulator RecX -
  EL136_RS00945 (NCTC6180_00194) - 182397..183365 (+) 969 WP_012516123.1 helix-hairpin-helix domain-containing protein -
  EL136_RS00950 (NCTC6180_00195) rlmD 183362..184729 (+) 1368 WP_154803610.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  EL136_RS00955 (NCTC6180_00196) - 185050..185307 (+) 258 WP_043030068.1 Blp family class II bacteriocin -
  EL136_RS00960 (NCTC6180_00197) - 185324..185518 (+) 195 WP_038674052.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  EL136_RS00965 (NCTC6180_00198) comE/blpR 186152..186901 (+) 750 WP_111690344.1 LytR/AlgR family response regulator transcription factor Regulator
  EL136_RS00970 (NCTC6180_00199) - 186901..188235 (+) 1335 WP_154803611.1 sensor histidine kinase -
  EL136_RS00975 (NCTC6180_00200) - 188357..188488 (-) 132 WP_154803612.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EL136_RS00980 (NCTC6180_00201) - 188588..189946 (-) 1359 WP_154803613.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29217.65 Da        Isoelectric Point: 8.4602

>NTDB_id=1121257 EL136_RS00965 WP_111690344.1 186152..186901(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MRVVILEDDMIQQRYLEKLIKELEVKHQLLFQGLDCFGRSHQLLSAIKKNCGQQLFFLDIEIKNEDKKGLEVARQIRQIN
PDAMIVFVTTHSEFMPLAFQYQVSALDYIDKELPHTEFVQRVETALLYAVRQNSETIAESAFYFTSRYAQVQVPFNDILY
IETSSRAHRVNLYTKKERMQFTGTLTDILKQESRFLQCHRSFLINPRNVVRVDKIERVVYFRNGSSCLIARSKMNSVLTT
IENLHRGDN

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1121257 EL136_RS00965 WP_111690344.1 186152..186901(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
GTGAGAGTAGTTATTTTAGAAGATGATATGATTCAGCAGAGATATTTAGAAAAGCTCATTAAAGAGCTTGAGGTTAAGCA
CCAGCTATTATTTCAAGGACTTGACTGTTTTGGAAGGTCTCACCAGCTATTAAGTGCTATCAAGAAGAACTGTGGTCAGC
AGCTATTCTTTTTAGATATTGAGATAAAAAATGAGGACAAAAAAGGGCTTGAGGTTGCTAGGCAAATTCGTCAGATAAAT
CCAGATGCGATGATTGTTTTTGTAACGACTCACTCGGAATTTATGCCCTTGGCTTTTCAGTATCAGGTATCTGCTTTGGA
CTATATCGATAAAGAGCTGCCTCACACTGAGTTTGTTCAACGGGTAGAGACTGCTTTATTATATGCTGTGCGGCAAAATA
GTGAAACGATAGCGGAAAGTGCTTTTTATTTTACATCTCGTTATGCTCAGGTACAGGTGCCTTTTAATGATATCCTGTAT
ATTGAGACATCGTCACGAGCGCATCGTGTCAATTTGTATACAAAAAAGGAGAGAATGCAATTTACAGGGACTTTGACGGA
TATTTTGAAGCAAGAGTCTCGTTTTTTGCAATGTCATCGTTCTTTTTTGATTAATCCTAGGAATGTCGTTAGGGTAGATA
AGATTGAGCGAGTGGTTTATTTTCGAAATGGCTCTAGCTGCTTAATTGCTCGTAGTAAAATGAACAGTGTTTTAACAACA
ATTGAGAACCTACATAGAGGAGATAATTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.522
  comE/comE1 Streptococcus equinus JB1

40.586

95.984

0.39
  comE/comE2 Streptococcus equinus JB1

36.29

99.598

0.361

Multiple sequence alignment