Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EL079_RS03435 Genome accession   NZ_LR134283
Coordinates   692723..693397 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain NCTC10713     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 687723..698397
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL079_RS03425 (NCTC10713_00726) - 689461..690909 (+) 1449 WP_003032171.1 alpha-amylase -
  EL079_RS03430 (NCTC10713_00727) ciaH 691387..692733 (-) 1347 WP_003024354.1 cell wall metabolism sensor histidine kinase WalK Regulator
  EL079_RS03435 (NCTC10713_00728) ciaR 692723..693397 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  EL079_RS03440 (NCTC10713_00729) - 693670..694128 (-) 459 WP_003032188.1 hypothetical protein -
  EL079_RS03445 (NCTC10713_00730) - 694470..695213 (-) 744 WP_003032183.1 alpha/beta fold hydrolase -
  EL079_RS03450 (NCTC10713_00731) - 695624..695872 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  EL079_RS03455 (NCTC10713_00732) - 695869..696165 (+) 297 WP_003024343.1 type II toxin-antitoxin system RelE/ParE family toxin -
  EL079_RS03460 (NCTC10713_00733) - 696275..697030 (-) 756 WP_003031299.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=1120015 EL079_RS03435 WP_003024352.1 692723..693397(-) (ciaR) [Streptococcus anginosus strain NCTC10713]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1120015 EL079_RS03435 WP_003024352.1 692723..693397(-) (ciaR) [Streptococcus anginosus strain NCTC10713]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATCTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAACGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGTACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment