Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ELZ47_RS06990 Genome accession   NZ_LR134002
Coordinates   1375895..1376569 (-) Length   224 a.a.
NCBI ID   WP_002909955.1    Uniprot ID   A0AAJ5NJ31
Organism   Streptococcus sanguinis strain NCTC 10904     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1370895..1381569
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ47_RS06970 (NCTC10904_01370) - 1371602..1372999 (-) 1398 WP_125332543.1 polysaccharide deacetylase family protein -
  ELZ47_RS06975 (NCTC10904_01371) - 1373061..1373447 (-) 387 WP_002895748.1 VOC family protein -
  ELZ47_RS06980 (NCTC10904_01372) - 1373560..1374498 (-) 939 WP_125332541.1 ketopantoate reductase family protein -
  ELZ47_RS06985 (NCTC10904_01373) ciaH 1374514..1375905 (-) 1392 WP_002915424.1 sensor histidine kinase Regulator
  ELZ47_RS06990 (NCTC10904_01374) ciaR 1375895..1376569 (-) 675 WP_002909955.1 response regulator transcription factor Regulator
  ELZ47_RS06995 (NCTC10904_01375) - 1376676..1377158 (-) 483 WP_125332539.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25252.03 Da        Isoelectric Point: 4.4858

>NTDB_id=1117821 ELZ47_RS06990 WP_002909955.1 1375895..1376569(-) (ciaR) [Streptococcus sanguinis strain NCTC 10904]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTLKAGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTTFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1117821 ELZ47_RS06990 WP_002909955.1 1375895..1376569(-) (ciaR) [Streptococcus sanguinis strain NCTC 10904]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTGGATGATTTTGCAGATGT
AATGCAGGTTTTTGATGGTGAAGAAGGTCTATATGAAGCAGAGAGCGGTGTTTATGACCTTATCTTGCTGGATCTCATGC
TTCCTGAAAAGGATGGTTTTCAAGTGCTGAAAGATCTTCGGGCAAAAGGAGTCACAACCCCTGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTCGGCGCTGATGATTATCTGACCAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAAGCGCTCTTGAAACGTGCTGGTAAATTCAACGAAAATACTCTTTCTTATGGTGATGTGACAG
TCAATCTATCCACAAATTCAACATTGAAAGCCGGTAAAGACGTAGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACCCAAATTTTTGACCGTCTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTTGAAGTGTACGTTTCCAAGATTCGTAAAAAACTGAAAGGAACGACATTTGCGAAAAACTTGCATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

89.286

100

0.893
  ciaR Streptococcus pneumoniae D39

89.286

100

0.893
  ciaR Streptococcus pneumoniae R6

89.286

100

0.893
  ciaR Streptococcus pneumoniae TIGR4

89.286

100

0.893
  ciaR Streptococcus mutans UA159

87.892

99.554

0.875
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment