Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ELZ47_RS06985 Genome accession   NZ_LR134002
Coordinates   1374514..1375905 (-) Length   463 a.a.
NCBI ID   WP_002915424.1    Uniprot ID   A0AAJ5NHX2
Organism   Streptococcus sanguinis strain NCTC 10904     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1369514..1380905
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ47_RS06965 (NCTC10904_01369) - 1370417..1371508 (+) 1092 WP_164549576.1 DEAD/DEAH box helicase -
  ELZ47_RS06970 (NCTC10904_01370) - 1371602..1372999 (-) 1398 WP_125332543.1 polysaccharide deacetylase family protein -
  ELZ47_RS06975 (NCTC10904_01371) - 1373061..1373447 (-) 387 WP_002895748.1 VOC family protein -
  ELZ47_RS06980 (NCTC10904_01372) - 1373560..1374498 (-) 939 WP_125332541.1 ketopantoate reductase family protein -
  ELZ47_RS06985 (NCTC10904_01373) ciaH 1374514..1375905 (-) 1392 WP_002915424.1 sensor histidine kinase Regulator
  ELZ47_RS06990 (NCTC10904_01374) ciaR 1375895..1376569 (-) 675 WP_002909955.1 response regulator transcription factor Regulator
  ELZ47_RS06995 (NCTC10904_01375) - 1376676..1377158 (-) 483 WP_125332539.1 hypothetical protein -

Sequence

Protein


Download         Length: 463 a.a.        Molecular weight: 52605.97 Da        Isoelectric Point: 8.4911

>NTDB_id=1117820 ELZ47_RS06985 WP_002915424.1 1374514..1375905(-) (ciaH) [Streptococcus sanguinis strain NCTC 10904]
MLNKIKKTFYADDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTSVDENLKNLSNDPSSVADLAYRTTGQQSDPSNKVN
TKSPKSSKEPDGDPNEEPKPDNLTTPNFSSNTFALLLDDNYKNISTSKSDGFLDFNSLDFNKSYLNQIKEIVIGNSFGQT
ESYRAYLFDIDPNNEYPDIKYAVVMTSISQLEQTSGKHEQLIAMVMVSFWGISLIASIYLARMSVKPLLESIQKQKAFVE
NASHELRTPLAVLQSRLETLFRKPEATIMQSSENIASSLDEVRNMRLLTTNLLNLARRDDGIKPQYGEVEPEFFDTTFAN
YCIIARENKKAFHSENMIKNPIVTDQIFLKQLMTILFDNAIKYTDDDGEISVMAASTDRYLIFRVADNGPGISNEDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAKQIVDAFKGTIYVKDNKPKGTVFEVKLLLKETKKRSVK

Nucleotide


Download         Length: 1392 bp        

>NTDB_id=1117820 ELZ47_RS06985 WP_002915424.1 1374514..1375905(-) (ciaH) [Streptococcus sanguinis strain NCTC 10904]
ATGCTGAATAAAATCAAGAAGACCTTTTATGCGGATGATTTCTCTTATTTCATTCGCTATTTTGGGCTGTTTACATTAAT
CTTCTCAGCCATGACCTTGATTATTATTCAGGTTATGCGCTCCAGCCTTTATACGTCTGTTGATGAAAATCTTAAAAACC
TGAGTAATGATCCTAGTTCGGTAGCAGATTTGGCCTATCGGACGACAGGTCAGCAGTCTGATCCGAGCAATAAGGTCAAC
ACTAAAAGTCCTAAAAGCAGTAAAGAACCAGATGGCGATCCAAACGAAGAGCCTAAGCCTGACAATCTGACGACGCCAAA
TTTCAGTTCTAATACTTTCGCCCTGCTTTTGGATGATAATTATAAAAATATTTCCACCAGCAAGAGCGATGGCTTTCTGG
ACTTTAATTCCTTGGACTTTAACAAGTCCTATCTGAATCAGATTAAGGAAATTGTGATTGGCAATAGCTTTGGCCAGACA
GAAAGCTACCGGGCTTATCTCTTTGATATTGACCCTAATAATGAATATCCAGATATCAAGTATGCTGTGGTCATGACTAG
CATCAGTCAGCTGGAGCAGACTAGCGGTAAGCATGAGCAACTGATTGCCATGGTTATGGTCAGCTTTTGGGGGATTTCCT
TGATTGCCAGTATTTATCTGGCTCGGATGAGTGTCAAGCCCTTGCTGGAAAGTATCCAGAAGCAGAAGGCTTTCGTGGAA
AATGCCAGTCACGAGCTGCGGACACCATTGGCTGTTTTGCAGAGCCGCTTAGAGACGCTCTTTCGTAAGCCTGAAGCTAC
AATTATGCAGAGCAGTGAAAATATCGCTTCTAGCTTGGATGAAGTGCGCAATATGCGCTTGCTGACGACCAATTTGCTAA
ATCTGGCTCGTCGCGATGATGGTATTAAGCCCCAATATGGTGAGGTAGAACCGGAGTTCTTTGATACGACCTTTGCTAAT
TACTGCATTATCGCAAGGGAAAATAAAAAAGCTTTTCATTCAGAAAATATGATCAAGAACCCCATTGTGACAGATCAAAT
TTTCCTCAAGCAGCTGATGACTATCCTATTTGACAATGCTATCAAGTACACAGATGATGACGGCGAAATCAGTGTTATGG
CTGCTTCAACCGATCGTTACCTCATCTTTCGGGTAGCAGATAATGGACCTGGTATCAGCAACGAAGATAAGAAGAAGATT
TTTGATCGCTTTTATCGGGTGGATAAGGCTCGGACCCGTCAGAAAGGTGGCTTTGGTCTGGGACTTTCTCTGGCCAAGCA
GATTGTCGATGCTTTCAAGGGCACCATTTATGTCAAGGACAACAAACCAAAAGGTACGGTCTTTGAAGTTAAACTGCTAT
TGAAAGAAACGAAAAAGCGTTCTGTAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(344-454)

His Kinase A (phospho-acceptor) domain (HisKA)

(236-301)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae D39

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae R6

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae TIGR4

60.738

99.568

0.605
  ciaH Streptococcus mutans UA159

52.632

98.488

0.518

Multiple sequence alignment