Detailed information NTG1116681

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: EW023_RS04735
• Genome accession: NZ_LR130239
• Coordinates: 907485..908321 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain PS003 isolate PS003
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 902485..913321

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW023_RS04705	-	903039..903407 (+)	369	WP_010922310.1	hypothetical protein	-
EW023_RS04710	-	903457..904368 (-)	912	WP_023612012.1	diacylglycerol/lipid kinase family protein	-
EW023_RS04715	trhA	904485..905135 (-)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
EW023_RS04720	-	905132..905572 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
EW023_RS04725	ylqF	905791..906639 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
EW023_RS04730	-	906629..907420 (+)	792	WP_023612045.1	ribonuclease HII	-
EW023_RS04735	dprA	907485..908321 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
EW023_RS04740	topA	908429..910558 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
EW023_RS09720	-	910633..911517 (-)	885	Protein_872	LysR family transcriptional regulator	-
EW023_RS04755	-	911530..912096 (+)	567	Protein_873	PTS sugar transporter subunit IIC	-
EW023_RS04760	-	912111..913103 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=1116681 EW023_RS04735 WP_023611998.1 907485..908321(+) (dprA) [Streptococcus pyogenes strain PS003 isolate PS003]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1116681 EW023_RS04735 WP_023611998.1 907485..908321(+) (dprA) [Streptococcus pyogenes strain PS003 isolate PS003]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367