Detailed information NTG1116568

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: EW024_RS04870
• Genome accession: NZ_LR130237
• Coordinates: 932108..932944 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain SP444 isolate SP444
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 927108..937944

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW024_RS04840	-	927596..928030 (+)	435	WP_021299262.1	hypothetical protein	-
EW024_RS04845	-	928080..928991 (-)	912	WP_011528643.1	diacylglycerol/lipid kinase family protein	-
EW024_RS04850	trhA	929108..929758 (-)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
EW024_RS04855	-	929755..930195 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
EW024_RS04860	ylqF	930414..931262 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
EW024_RS04865	-	931252..932043 (+)	792	WP_011017771.1	ribonuclease HII	-
EW024_RS04870	dprA	932108..932944 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
EW024_RS04875	topA	933051..935180 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
EW024_RS09280	-	935256..936140 (-)	885	Protein_887	LysR family transcriptional regulator	-
EW024_RS04890	-	936153..936719 (+)	567	Protein_888	PTS sugar transporter subunit IIC	-
EW024_RS04895	-	936734..937726 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=1116568 EW024_RS04870 WP_011017772.1 932108..932944(+) (dprA) [Streptococcus pyogenes strain SP444 isolate SP444]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1116568 EW024_RS04870 WP_011017772.1 932108..932944(+) (dprA) [Streptococcus pyogenes strain SP444 isolate SP444]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367