Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   A66_RS05545 Genome accession   NZ_LN847353
Coordinates   1075733..1076437 (-) Length   234 a.a.
NCBI ID   WP_053039628.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain A66     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1070733..1081437
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A66_RS05520 (A66_01103) - 1071045..1072916 (-) 1872 WP_053039627.1 Eco57I restriction-modification methylase domain-containing protein -
  A66_RS05525 (A66_01104) - 1072991..1073245 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  A66_RS05530 (A66_01105) relB 1073247..1073489 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  A66_RS05535 (A66_01106) vicX 1073580..1074389 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  A66_RS05540 (A66_01107) micB 1074391..1075740 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  A66_RS05545 (A66_01108) micA 1075733..1076437 (-) 705 WP_053039628.1 response regulator YycF Regulator
  A66_RS05550 (A66_01109) mutY 1076493..1077668 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  A66_RS12780 (A66_01110) - 1077765..1077890 (+) 126 WP_001818232.1 hypothetical protein -
  A66_RS05555 (A66_01111) - 1077996..1079666 (-) 1671 WP_053039629.1 formate--tetrahydrofolate ligase -
  A66_RS05560 (A66_01112) coaB 1079896..1080585 (+) 690 WP_053039630.1 phosphopantothenate--cysteine ligase -
  A66_RS05565 (A66_01113) coaC 1080597..1081148 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26891.73 Da        Isoelectric Point: 4.7164

>NTDB_id=1114571 A66_RS05545 WP_053039628.1 1075733..1076437(-) (micA) [Streptococcus pneumoniae strain A66]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFYNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1114571 A66_RS05545 WP_053039628.1 1075733..1076437(-) (micA) [Streptococcus pneumoniae strain A66]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTACAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

99.573

100

0.996
  vicR Streptococcus mutans UA159

78.112

99.573

0.778
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment