Detailed information NTG1114401

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AT689_RS07790
• Genome accession: NZ_LN831051
• Coordinates: 1453799..1454503 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain NCTC7465
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1448799..1459503

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AT689_RS07770 (ERS445053_01523)	coaC	1449088..1449639 (-)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-
AT689_RS07775 (ERS445053_01524)	coaB	1449651..1450340 (-)	690	WP_000699503.1	phosphopantothenate--cysteine ligase	-
AT689_RS07780 (ERS445053_01525)	-	1450570..1452240 (+)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
AT689_RS13500	-	1452346..1452471 (-)	126	WP_001818232.1	hypothetical protein	-
AT689_RS07785 (ERS445053_01526)	mutY	1452568..1453743 (+)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
AT689_RS07790 (ERS445053_01527)	micA	1453799..1454503 (+)	705	WP_000722076.1	response regulator YycF	Regulator
AT689_RS07795 (ERS445053_01528)	micB	1454496..1455845 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AT689_RS07800 (ERS445053_01529)	vicX	1455847..1456656 (+)	810	WP_001289496.1	MBL fold metallo-hydrolase	Regulator
AT689_RS07805 (ERS445053_01530)	relB	1456747..1456989 (+)	243	WP_012677101.1	type II toxin-antitoxin system RelB family antitoxin	-
AT689_RS07810 (ERS445053_01531)	-	1456991..1457245 (+)	255	WP_001823540.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AT689_RS07815 (ERS445053_01532)	-	1457292..1458035 (+)	744	WP_000725952.1	potassium channel family protein	-
AT689_RS07820 (ERS445053_01533)	-	1458325..1459311 (-)	987	WP_000204727.1	L-lactate dehydrogenase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1114401 AT689_RS07790 WP_000722076.1 1453799..1454503(+) (micA) [Streptococcus pneumoniae strain NCTC7465]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1114401 AT689_RS07790 WP_000722076.1 1453799..1454503(+) (micA) [Streptococcus pneumoniae strain NCTC7465]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38