Detailed information NTG0111269

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: F601_RS0104625
• Genome accession: NZ_AQYA01000030
• Coordinates: 7782..8693 (+)
• Length: 303 a.a.
• NCBI ID: WP_018164503.1
• Uniprot ID: A0A1G6BIT0
• Organism: Streptococcus henryi DSM 19005
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 2782..13693

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F601_RS0104600	-	3036..3491 (+)	456	WP_018164498.1	DUF523 domain-containing protein	-
F601_RS0104605	purE	3656..4144 (+)	489	WP_026183109.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
F601_RS0104610	purK	4131..5213 (+)	1083	WP_018164500.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
F601_RS0104615	-	5271..5972 (+)	702	WP_248678594.1	hypothetical protein	-
F601_RS0104620	purB	6269..7567 (+)	1299	WP_018164502.1	adenylosuccinate lyase	-
F601_RS0104625	comR	7782..8693 (+)	912	WP_018164503.1	helix-turn-helix domain-containing protein	Regulator
F601_RS13375	comS	8781..8882 (+)	102	WP_018164504.1	quorum-sensing system DWW-type pheromone	Regulator
F601_RS0104635	-	8939..9187 (+)	249	WP_018164505.1	hypothetical protein	-
F601_RS0104640	ruvB	9252..10253 (+)	1002	WP_026183110.1	Holliday junction branch migration DNA helicase RuvB	-
F601_RS0104645	-	10436..10870 (+)	435	WP_018164507.1	low molecular weight protein-tyrosine-phosphatase	-
F601_RS0104650	-	10881..11261 (+)	381	WP_018164508.1	hypothetical protein	-
F601_RS0104655	-	11258..13042 (+)	1785	WP_018164509.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35513.60 Da
• Isoelectric Point: 4.4984

>NTDB_id=111269 F601_RS0104625 WP_018164503.1 7782..8693(+) (comR) [Streptococcus henryi DSM 19005]
MKETFGEKVRLLREGKQLTREEFCGDETELSIRQLARIESGKSTPNLARAQFIAQQLGVGLGELTDGKSLELPKRYTELK
YLILRTPTYMDAERLRIREEQFDEIYEKFYEELPEDEQLTITFIQSKFEVYQTGDTEFGTDVIEDYFKQVQKKKLYTLND
IVLIDLFLTCSIVSNFTSHLFDNAIYELLSSNLIKQSEYLPIEDLPLLNSVLLVCADASVRLEKFNLLSNLLSASHSLMT
KIQDFQKMPIYNMLMWEYYLFGENNYVQAENHYNQSILFAKMMNDIHLAEKLEKEWEMDNLGK

Nucleotide

• Length: 912 bp

>NTDB_id=111269 F601_RS0104625 WP_018164503.1 7782..8693(+) (comR) [Streptococcus henryi DSM 19005]
ATGAAGGAGACATTTGGAGAAAAAGTCAGATTGCTTAGAGAAGGGAAACAACTGACTCGTGAAGAGTTTTGTGGAGATGA
AACAGAATTGTCAATCCGCCAGTTGGCCAGAATAGAATCAGGGAAATCCACCCCTAATCTAGCCAGAGCACAATTTATAG
CTCAACAATTAGGAGTAGGACTCGGAGAACTAACAGACGGAAAAAGTCTGGAGCTTCCTAAGAGGTATACTGAGTTGAAG
TACTTAATATTAAGAACACCAACTTACATGGATGCAGAACGATTAAGAATCAGAGAAGAGCAGTTTGATGAGATTTACGA
GAAATTTTATGAAGAGTTACCTGAAGATGAGCAGCTTACAATAACATTTATCCAATCAAAGTTTGAAGTTTATCAAACAG
GAGATACTGAATTTGGAACGGATGTTATTGAAGATTATTTTAAGCAAGTTCAAAAAAAGAAGTTATACACATTAAATGAT
ATAGTGTTAATTGATTTATTCTTAACATGTTCAATTGTGTCGAATTTTACGTCACATCTTTTTGATAATGCTATCTATGA
ATTGCTGTCATCTAATCTTATTAAACAAAGTGAATATCTTCCAATAGAAGATTTACCACTATTAAATAGTGTTTTGCTTG
TTTGCGCAGATGCCTCTGTAAGACTTGAAAAATTTAATTTACTTAGTAATCTACTTTCCGCTAGTCATTCTTTAATGACT
AAGATTCAGGATTTTCAAAAAATGCCAATCTATAATATGTTGATGTGGGAATACTATTTGTTTGGAGAAAATAATTATGT
TCAGGCAGAAAATCATTATAACCAATCAATATTATTTGCCAAGATGATGAATGATATCCATTTAGCTGAAAAATTGGAAA
AAGAGTGGGAGATGGATAATTTAGGGAAATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (10-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A1G6BIT0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	51.505	98.68	0.508
comR	Streptococcus mutans UA159	47.667	99.01	0.472
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.181	95.05	0.439
comR	Streptococcus pyogenes MGAS8232	42.475	98.68	0.419
comR	Streptococcus suis P1/7	38.176	97.69	0.373
comR	Streptococcus suis 05ZYH33	38.176	97.69	0.373