Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE1   Type   Regulator
Locus tag   HMPREF9319_RS08785 Genome accession   NZ_GL397128
Coordinates   1831250..1831933 (-) Length   227 a.a.
NCBI ID   WP_003066571.1    Uniprot ID   E0PG59
Organism   Streptococcus equinus ATCC 700338     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1826250..1836933
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF9319_RS08750 (HMPREF9319_1822) - 1826520..1826747 (-) 228 WP_003066551.1 hypothetical protein -
  HMPREF9319_RS11215 (HMPREF9319_1823) comD/comD3 1826879..1827193 (-) 315 WP_003066552.1 GHKL domain-containing protein Regulator
  HMPREF9319_RS11220 - 1827373..1827582 (-) 210 WP_231729916.1 hypothetical protein -
  HMPREF9319_RS10840 (HMPREF9319_1826) comE/comE2 1827595..1827816 (-) 222 WP_003066558.1 LytTR family transcriptional regulator DNA-binding domain-containing protein Regulator
  HMPREF9319_RS08760 (HMPREF9319_1827) - 1827788..1828150 (-) 363 WP_003066560.1 bacteriocin immunity protein -
  HMPREF9319_RS08770 (HMPREF9319_1829) - 1828707..1829018 (-) 312 WP_003066564.1 bacteriocin immunity protein -
  HMPREF9319_RS08775 (HMPREF9319_1830) - 1829776..1829913 (+) 138 WP_003066566.1 hypothetical protein -
  HMPREF9319_RS08780 (HMPREF9319_1831) - 1829935..1831242 (-) 1308 WP_003066569.1 sensor histidine kinase -
  HMPREF9319_RS08785 (HMPREF9319_1832) comE/comE1 1831250..1831933 (-) 684 WP_003066571.1 response regulator transcription factor Regulator
  HMPREF9319_RS08790 (HMPREF9319_1833) - 1831998..1832282 (-) 285 WP_003066573.1 LytTR family DNA-binding domain-containing protein -
  HMPREF9319_RS08800 (HMPREF9319_1835) - 1832979..1833992 (-) 1014 WP_003066577.1 hypothetical protein -
  HMPREF9319_RS08805 (HMPREF9319_1836) - 1834164..1834460 (-) 297 WP_003066579.1 bacteriocin immunity protein -
  HMPREF9319_RS08810 (HMPREF9319_1837) - 1834460..1834678 (-) 219 WP_003066580.1 Blp family class II bacteriocin -
  HMPREF9319_RS11485 - 1834871..1834990 (-) 120 WP_253066439.1 CPBP family glutamic-type intramembrane protease -
  HMPREF9319_RS11225 (HMPREF9319_1838) - 1834987..1835307 (-) 321 WP_231557401.1 CPBP family intramembrane glutamic endopeptidase -
  HMPREF9319_RS11230 (HMPREF9319_1839) - 1835364..1835543 (-) 180 WP_003066584.1 hypothetical protein -
  HMPREF9319_RS08825 (HMPREF9319_1840) - 1835714..1836025 (-) 312 WP_003066586.1 hypothetical protein -
  HMPREF9319_RS08830 (HMPREF9319_1841) - 1836114..1836344 (-) 231 WP_003066588.1 bacteriocin -

Sequence

Protein


Download         Length: 227 a.a.        Molecular weight: 26426.14 Da        Isoelectric Point: 5.6797

>NTDB_id=1111704 HMPREF9319_RS08785 WP_003066571.1 1831250..1831933(-) (comE/comE1) [Streptococcus equinus ATCC 700338]
MEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREQDATAIIVFVTTHSEFM
LLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRVLYSDILYFETSPAVHRVILHTR
NERVEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDSCLVSRDKIKPLLNEMR

Nucleotide


Download         Length: 684 bp        

>NTDB_id=1111704 HMPREF9319_RS08785 WP_003066571.1 1831250..1831933(-) (comE/comE1) [Streptococcus equinus ATCC 700338]
ATGGAACGCGAGATTGCGACCATTATGGCAAAAAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGA
GATTATAGCTAAGGCAACTGAAAAAGGAGAGCATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAG
GAATTGATGTCGCTAAAGCCATTCGTGAACAAGATGCAACGGCTATCATTGTTTTTGTAACAACCCATTCAGAATTTATG
CTGCTGACTTACCAAGCGTTAGTAGGGGCGATTGATTTTATTGATAAGAACCTGAATGACCAAGCATTTAGTGAACGCAT
AGAGTTGTGCCTAAAGGAAGCCATGAAACATCAAAATGATAATTTCGGCGAGAATTCCTTTTTGTTTGAAACTCCTAAAG
CACGTGTGCGCGTTCTATATAGTGACATTCTTTATTTCGAAACATCTCCTGCCGTGCACCGTGTGATTTTGCATACGAGA
AATGAAAGAGTGGAATTTTATGCGACGATTGCAGAGATTGCTAAATCAGACAAACGTCTTTTCAAGTGTCACCGTTCTTT
TATCATTAATGTGGATAATGTGGTCAGATTTGATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACTCTTGCTTAG
TTTCGAGGGATAAAATAAAACCTCTATTGAATGAGATGAGGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(136-222)

Response regulator receiver domain (Response_reg)

(10-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E0PG59

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus equinus JB1

70.925

100

0.709
  comE/blpR Streptococcus mutans UA159

48.43

98.238

0.476
  comE/comE2 Streptococcus equinus JB1

43.363

99.559

0.432

Multiple sequence alignment