Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACN076_RS07260 Genome accession   NZ_CP184836
Coordinates   1484178..1484852 (-) Length   224 a.a.
NCBI ID   WP_060805708.1    Uniprot ID   -
Organism   Streptococcus sp. K0074     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1479178..1489852
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACN076_RS07255 (ACN076_07255) ciaH 1482854..1484188 (-) 1335 WP_153193329.1 two-component system sensor histidine kinase CiaH Regulator
  ACN076_RS07260 (ACN076_07260) ciaR 1484178..1484852 (-) 675 WP_060805708.1 two-component system response regulator CiaR Regulator
  ACN076_RS07265 (ACN076_07265) - 1484961..1487507 (-) 2547 WP_261219218.1 M1 family metallopeptidase -
  ACN076_RS07270 (ACN076_07270) - 1487629..1488069 (-) 441 WP_101782032.1 ASCH domain-containing protein -
  ACN076_RS07275 (ACN076_07275) - 1488029..1488913 (-) 885 WP_261023939.1 putative PEP-binding protein -
  ACN076_RS07280 (ACN076_07280) - 1488891..1489391 (-) 501 WP_261023919.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=1111461 ACN076_RS07260 WP_060805708.1 1484178..1484852(-) (ciaR) [Streptococcus sp. K0074]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1111461 ACN076_RS07260 WP_060805708.1 1484178..1484852(-) (ciaR) [Streptococcus sp. K0074]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTTTGCTCGATTTGATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACTTAGAAGA
ACTCAAAATGAGAATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACTTATGGAAATATTGTAG
TTAATTTGTCAACCAATACTGTTAAGGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTTTATGGGGATTTGATAGTGACACAACAAT
TTCAGTTGTCGAAGTCTATGTTTCAAAAATTCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.107

100

0.991
  ciaR Streptococcus pneumoniae D39

99.107

100

0.991
  ciaR Streptococcus pneumoniae R6

99.107

100

0.991
  ciaR Streptococcus pneumoniae TIGR4

99.107

100

0.991
  ciaR Streptococcus mutans UA159

89.286

100

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment