Detailed information NTG1111416

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACN076_RS01000
• Genome accession: NZ_CP184836
• Coordinates: 178207..180360 (-)
• Length: 717 a.a.
• NCBI ID: WP_420789989.1
• Uniprot ID: -
• Organism: Streptococcus sp. K0074
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 173207..185360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACN076_RS00990 (ACN076_00990)	purC	175968..176675 (-)	708	WP_420789987.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ACN076_RS00995 (ACN076_00995)	comB	176845..178194 (-)	1350	WP_420789988.1	competence pheromone export protein ComB	Regulator
ACN076_RS01000 (ACN076_01000)	comA	178207..180360 (-)	2154	WP_420789989.1	peptide cleavage/export ABC transporter ComA	Regulator
ACN076_RS01005 (ACN076_01005)	-	180662..180850 (-)	189	WP_000757184.1	hypothetical protein	-
ACN076_RS01010 (ACN076_01010)	-	181509..181724 (-)	216	WP_080673747.1	bacteriocin immunity protein	-
ACN076_RS01015 (ACN076_01015)	-	181728..181883 (-)	156	WP_000357248.1	smi_0061 family bacteriocin-like peptide	-
ACN076_RS01020 (ACN076_01020)	-	182097..182294 (-)	198	WP_000180818.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACN076_RS01025 (ACN076_01025)	-	182328..182483 (-)	156	WP_049499436.1	hypothetical protein	-
ACN076_RS01030 (ACN076_01030)	-	182494..182622 (-)	129	WP_049499438.1	smi_0059.1 family bacteriocin-like peptide	-
ACN076_RS01035 (ACN076_01035)	-	183121..183852 (-)	732	WP_001221869.1	response regulator transcription factor	-
ACN076_RS01040 (ACN076_01040)	-	183864..184712 (-)	849	WP_420789990.1	GHKL domain-containing protein	-
ACN076_RS01045 (ACN076_01045)	-	185218..185352 (-)	135	WP_000425302.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80210.34 Da
• Isoelectric Point: 6.6494

>NTDB_id=1111416 ACN076_RS01000 WP_420789989.1 178207..180360(-) (comA) [Streptococcus sp. K0074]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVIGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLILFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVAYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVSYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILDNLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLARGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=1111416 ACN076_RS01000 WP_420789989.1 178207..180360(-) (comA) [Streptococcus sp. K0074]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACAACCATGGATGGGACAACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCTCATGTGCTTAAGGAAGGGAAATTGCTTCACTACTATGTGGTGATTGGGCAGGATAAGGATAG
CATTCATATTGCCGACCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACCCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAAAATGGACTTCTTTCCTTTATACCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATTTGCAGTCTATCATTGATACCTATGTACCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTGGTCA
TCGTTTATATTCTCCAGCAGATCTTGTCTTATGCTCAGGAATATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGTCGGACAGGGGAAATCGTGTC
TCGTTTCACGGATGCTAATAGTATCATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTATCAACGGTTG
TCATTATTTCTCTTATTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCACTTCCTATCTACACAGTG
ATTATCTTTGCATTTATGAAGCCGTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTGCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTCAGCGTTACCAAAAGATTGATAAGGAAT
TTGTAGCTTATCTGAAGAAATCCTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGTATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACAAATCCTTTGGAAAATATCATCAACCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATCTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGATGTCTTGTCAGATATCAATTTGACTAT
TCCGCAGGGTTCTAAGGTGGCTTTTGTGGGGATTTCGGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAGGGAGAGATTAGTCTGGGTGGCGTCAATCTCAATCAGATTGATAAAAAGGCCTTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGACAATCTTCTTTTGGGAGCCAAGGAGGGAACGAC
TCAGGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGATATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGACGGGGCAGGAATCTCAGGTGGTCAACGTCAGAGAATCGCTCTGGCGCGTGCTCTCCTGACAGATGCA
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTAGATAATCTGATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTTGTAGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACGGGGTGGATTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	99.024	100	0.99
comA	Streptococcus pneumoniae Rx1	98.326	100	0.983
comA	Streptococcus pneumoniae D39	98.326	100	0.983
comA	Streptococcus pneumoniae R6	98.326	100	0.983
comA	Streptococcus mitis SK321	98.326	100	0.983
comA	Streptococcus pneumoniae TIGR4	97.908	100	0.979
comA	Streptococcus gordonii str. Challis substr. CH1	80.753	100	0.808
comA/nlmT	Streptococcus mutans UA159	65.272	100	0.653